Product nameAnti-AIMP2/p38 antibody
See all AIMP2/p38 primary antibodies
DescriptionRabbit polyclonal to AIMP2/p38
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Rat, Human
Predicted to work with: Mouse
Synthetic peptide from internal sequence amino acids of Human AIMP2/p38.
- Rat liver, lung, kidney, and brain lysates; Jurkat, CEM, HUT and U93T whole cell lysates.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab125218 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. The detection limit for ab125218 is 1ng/lane under non-reducing and reducing conditions.|
|IHC-P||Use a concentration of 1 µg/ml.|
FunctionRequired for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Sequence similaritiesContains 1 GST C-terminal domain.
modificationsPhosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
Cellular localizationCytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
- Information by UniProt
- Aimp2 antibody
- AIMP2_HUMAN antibody
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
All lanes : Anti-AIMP2/p38 antibody (ab125218) at 1 µg/ml
Lane 1 : Rat liver tissue lysate
Lane 2 : Rat lung tissue lysate
Lane 3 : Rat kidney tissue lysate
Lane 4 : Rat brain tissue lysate
Lane 5 : Rabbit IgG (55kDa)
Lane 6 : Jurkat whole cell lysate
Lane 7 : CEM whole cell lysate
Lane 8 : HUT whole cell lysate
Lane 9 : U93T whole cell lysate
Predicted band size: 35 kDa
ab125218 at 1ug/ml in paraffin embedded Human tumour tissue by immunohistochemistry.
ab125218 has not yet been referenced specifically in any publications.