Overview

  • Product name

  • Description

    Rabbit polyclonal to AIMP2/p38
  • Host species

    Rabbit
  • Specificity

    ab180897 is predicted to not cross-react with EMAP II.
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human AIMP2/p38 (internal sequence). (16 amino acid peptide; NP_006294).
    Database link: Q13155

  • Positive control

    • HeLa cell lysate; Rat small intestine tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab180897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 35 kDa).
IHC-P Use a concentration of 5 - 20 µg/ml.

Target

  • Function

    Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
  • Sequence similarities

    Contains 1 GST C-terminal domain.
  • Post-translational
    modifications

    Phosphorylated on serine residues in response to UV irradiation.
    Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Cellular localization

    Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Aimp2 antibody
    • AIMP2_HUMAN antibody
    • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
    • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
    • ARS interacting multi functional protein 2 antibody
    • JTV 1 antibody
    • JTV 1 protein antibody
    • JTV1 antibody
    • JTV1 gene antibody
    • Multisynthase complex auxiliary component p38 antibody
    • Multisynthetase complex auxiliary component p38 antibody
    • P38 antibody
    • PRO0992 antibody
    • Protein JTV 1 antibody
    • Protein JTV-1 antibody
    • tRNA SYNTHETASE COFACTOR p38 antibody
    see all

Images

  • All lanes : Anti-AIMP2/p38 antibody (ab180897) at 1 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 35 kDa
    Observed band size: 36 kDa
    why is the actual band size different from the predicted?

  • Immunohistochemical analysis of paraffin-embedded rat small intestine tissue labeling AIMP2/p38 with ab180897 at 5 μg/ml.

  • Immunohistochemical analysis of paraffin-embedded rat small intestine tissue labeling AIMP2/p38 with ab180897 at 20 µg/ml.

References

ab180897 has not yet been referenced specifically in any publications.

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