Key features and details
- Mouse polyclonal to AIMP2/p38
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-AIMP2/p38 antibody
See all AIMP2/p38 primary antibodies
DescriptionMouse polyclonal to AIMP2/p38
SpecificityThis antibody is reactive against mammalian transfected lysate.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Full length AIMP2/p38 protein (Human)
- AIMP2/p38 transfected 293T cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab67471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Detection Antibody Pair.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionRequired for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Sequence similaritiesContains 1 GST C-terminal domain.
modificationsPhosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
Cellular localizationCytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
- Information by UniProt
- Aimp2 antibody
- AIMP2_HUMAN antibody
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
All lanes : Anti-AIMP2/p38 antibody (ab67471) at 1/500 dilution
Lane 1 : AIMP2/p38 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa
ab67471 has not yet been referenced specifically in any publications.