Overview

  • Product name

  • Description

    Rabbit polyclonal to AIPL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISA, ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    A 17 amino acid synthetic peptide near the carboxy terminus of human AIPL1 (NP_055151).

  • Positive control

    • Human brain tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab79039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 44 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.

Target

  • Function

    May be important in protein trafficking and/or protein folding and stabilization.
  • Tissue specificity

    Highly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.
  • Involvement in disease

    Defects in AIPL1 are the cause of Leber congenital amaurosis type 4 (LCA4) [MIM:604393]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
  • Sequence similarities

    Contains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • A930007I01Rik antibody
    • Aipl1 antibody
    • AIPL1_HUMAN antibody
    • AIPL2 antibody
    • Aryl hydrocarbon interacting protein like 1 antibody
    • Aryl hydrocarbon receptor interacting protein like 1 antibody
    • Aryl-hydrocarbon-interacting protein-like 1 antibody
    • LCA4 antibody
    • MGC25485 antibody
    • OTTHUMP00000128207 antibody
    • OTTMUSP00000006382 antibody
    • RP23-401C17.1 antibody
    see all

Images

  • Immunofluorescence of AIPL1 in Human brain tissue with ab79039 at 20 ug/mL.

  • Immunohistochemistry of Human brain tisue using ab79039 at 2.5 μg/ml.

  • Lane 1 : Anti-AIPL1 antibody (ab79039) at 1 µg/ml
    Lane 2 : Anti-AIPL1 antibody (ab79039) at 2 µg/ml

    All lanes : Human brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 44 kDa
    Observed band size: 36 kDa
    why is the actual band size different from the predicted?

References

ab79039 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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