Overview

  • Product name

    Anti-AIPL1 antibody [EPR7711]
    See all AIPL1 primary antibodies
  • Description

    Rabbit monoclonal [EPR7711] to AIPL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human AIPL1 aa 350-450. The exact sequence is proprietary.

  • Positive control

    • Y79 cell lysate; permeabilized Y79 cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab128960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC/IF or IHC-P.
  • Target

    • Function

      May be important in protein trafficking and/or protein folding and stabilization.
    • Tissue specificity

      Highly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.
    • Involvement in disease

      Defects in AIPL1 are the cause of Leber congenital amaurosis type 4 (LCA4) [MIM:604393]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
    • Sequence similarities

      Contains 1 PPIase FKBP-type domain.
      Contains 3 TPR repeats.
    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • A930007I01Rik antibody
      • Aipl1 antibody
      • AIPL1_HUMAN antibody
      • AIPL2 antibody
      • Aryl hydrocarbon interacting protein like 1 antibody
      • Aryl hydrocarbon receptor interacting protein like 1 antibody
      • Aryl-hydrocarbon-interacting protein-like 1 antibody
      • LCA4 antibody
      • MGC25485 antibody
      • OTTHUMP00000128207 antibody
      • OTTMUSP00000006382 antibody
      • RP23-401C17.1 antibody
      see all

    Images

    • ab128960, at 1/10 dilution staining AIPL1 (red) in permeabilized Y79 cells, compared with a negative rabbit IgG (green) by flow cytometry.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD
    • Anti-AIPL1 antibody [EPR7711] (ab128960) at 1/10000 dilution + Y79 cell lysate at 10 µg

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 44 kDa
      Observed band size: 44 kDa

    References

    ab128960 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab128960.
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