Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7711] to AIPL1
- Suitable for: WB, IP, Flow Cyt
- Reacts with: Human
Product nameAnti-AIPL1 antibody [EPR7711]
See all AIPL1 primary antibodies
DescriptionRabbit monoclonal [EPR7711] to AIPL1
Tested applicationsSuitable for: WB, IP, Flow Cytmore details
Unsuitable for: ICC/IF or IHC-P
Species reactivityReacts with: Human
Synthetic peptide within Human AIPL1 aa 350-450. The exact sequence is proprietary.
- Y79 cell lysate; permeabilized Y79 cells.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Dissociation constant (KD)KD = 2.25 x 10 -11 M Learn more about KD
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab128960 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/10000 - 1/50000. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).|
|IP||1/10 - 1/100.|
|Flow Cyt||1/10 - 1/100.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
FunctionMay be important in protein trafficking and/or protein folding and stabilization.
Tissue specificityHighly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.
Involvement in diseaseDefects in AIPL1 are the cause of Leber congenital amaurosis type 4 (LCA4) [MIM:604393]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
Sequence similaritiesContains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- A930007I01Rik antibody
- Aipl1 antibody
- AIPL1_HUMAN antibody
ab128960, at 1/10 dilution staining AIPL1 (red) in permeabilized Y79 cells, compared with a negative rabbit IgG (green) by flow cytometry.
Equilibrium disassociation constant (KD)
Learn more about KD
Click here to learn more about KD
Anti-AIPL1 antibody [EPR7711] (ab128960) at 1/10000 dilution + Y79 cell lysate at 10 µg
HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa
ab128960 has not yet been referenced specifically in any publications.