Ajmalicine (Raubasine), alpha1-adrenoceptor antagonist (ab145408)

Overview

  • Product name

    Ajmalicine (Raubasine), alpha1-adrenoceptor antagonist
  • Description

    Selective α1-adrenoceptor antagonist. Reversible non-competitive nicotine receptor antagonist.
  • Biological description

    Selective competitive α1-adrenoceptor antagonist (pA2 = 6.57, noradrenaline). Reversible non-competitive nicotine receptor antagonist (IC50 = 72.3 μM). Competitively blocks the inhibitory effect of clonidine. Shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    483-04-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Pereira DM  et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine 17:646-52 (2010). Read more (PubMed: 19962870) »
  • Sebban C  et al. Comparative effects of almitrine and raubasine, singly and in combination, on electroencephalographic activity in young and old rats. Exp Gerontol 24:11-24 (1989). Read more (PubMed: 2707311) »
  • Demichel P & Roquebert J Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol 83:505-10 (1984). Read more (PubMed: 6091834) »

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