Overview

  • Product name

    AK-1, SIRT2 inhibitor
  • Description

    Cell-permeable SIRT2 inhibitor
  • Biological description

    Cell-permeable SIRT2 inhibitor (IC50 = 13 μM). Increases acetylated tubulin levels. Shows neuroprotective effects in vivo.
  • Purity

    > 99%
  • CAS Number

    330461-64-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lazo-Gómez R  et al. Histone deacetylases and their role in motor neuron degeneration. Front Cell Neurosci 7:243 (2013). Read more (PubMed: 24367290) »
  • Luthi-Carter R  et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A 107:7927-32 (2010). Read more (PubMed: 20378838) »
  • Outeiro TF  et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317:516-9 (2007). Read more (PubMed: 17588900) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144549.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up