• Product name
  • Description
    Goat polyclonal to AKAP10
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Dog, Human
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 28-40 of Human AKAP10 (NP_009133.2).

  • Positive control
    • Rat Brain lysate.


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab97684 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab97684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 74 kDa).


  • Function
    Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
  • Involvement in disease
    Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:115080]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
  • Sequence similarities
    Contains 2 RGS domains.
  • Domain
    RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Cellular localization
    Mitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1500031L16Rik antibody
    • A kinase (PRKA) anchor protein 10 antibody
    • A kinase anchor protein 10 antibody
    • A kinase anchor protein 10 mitochondrial antibody
    • A-kinase anchor protein 10 antibody
    • AKA10_HUMAN antibody
    • akap 10 antibody
    • AKAP-10 antibody
    • AKAP10 antibody
    • B130049N18Rik antibody
    • D AKAP 2 antibody
    • D-AKAP-2 antibody
    • dakap 2 antibody
    • dakap2 antibody
    • Dual specific A kinase anchoring protein 2 antibody
    • Dual specificity A kinase-anchoring protein 2 antibody
    • mgc9410 antibody
    • MGC9414| antibody
    • Mitochondrial A kinase PPKA anchor protein 10 antibody
    • mitochondrial antibody
    • prka 10 antibody
    • PRKA10 antibody
    • Protein A kinase anchoring protein 10 antibody
    • Protein A kinase anchoring protein 10 mitochondrial precursor antibody
    • Protein kinase A anchoring protein 10 antibody
    • Protein kinase A-anchoring protein 10 antibody
    see all


  • Anti-AKAP10 antibody (ab97684) at 1 µg/ml + Rat brain lysates at 35 µg

    Predicted band size: 74 kDa
    Observed band size: 74 kDa


ab97684 has not yet been referenced specifically in any publications.

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