Overview

  • Product name

    Anti-AKAP5 antibody
  • Description

    Rabbit polyclonal to AKAP5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human AKAP5 aa 161-234.
    Sequence:

    LDIQTQTPLNDQATKAKSTQDLSEGISRKDGDEVCESNVSNSITSGEKVI SVELGLDNGHSAIQTGTLILEEIE


    Database link: P24588

  • Positive control

    • RT-4 cell lysate; Human cerebal cortex tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab204082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250 - 1/500. Predicted molecular weight: 47 kDa.
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
  • Tissue specificity

    Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
  • Sequence similarities

    Contains 1 AKAP domain.
  • Domain

    RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Cellular localization

    Membrane. Associated with particulate fractions.
  • Information by UniProt
  • Database links

  • Alternative names

    • A kinase (PRKA) anchor protein 5 antibody
    • A kinase anchor protein 5 antibody
    • A kinase anchor protein 79kDa antibody
    • A kinase anchoring protein 75/79 antibody
    • A-kinase anchor protein 5 antibody
    • A-kinase anchor protein 79 kDa antibody
    • AKAP 5 antibody
    • AKAP 75 antibody
    • AKAP 79 antibody
    • AKAP-5 antibody
    • Akap5 antibody
    • AKAP5_HUMAN antibody
    • AKAP75 antibody
    • AKAP79 antibody
    • cAMP dependent protein kinase regulatory subunit II high affinity binding protein antibody
    • cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein antibody
    • H21 antibody
    see all

Images

  • Anti-AKAP5 antibody (ab204082) at 1/250 dilution + RT-4 cell lysate

    Developed using the ECL technique.

    Predicted band size: 47 kDa

  • Immunohistochemical analysis of paraffin embedded Human cerebral cortex tissue labeling AKAP5 with ab204082 at 1/50 dilution.

References

ab204082 has not yet been referenced specifically in any publications.

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