Overview

  • Product name

  • Description

    Rabbit polyclonal to AKR1A1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Cow, Pig
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1 - 131 of Human AKR1A1 (P14550).

  • Positive control

    • A549 whole cell lysate HepG2 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab125878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 37 kDa.

Target

  • Function

    Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
  • Tissue specificity

    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • Sequence similarities

    Belongs to the aldo/keto reductase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • AK1A1_HUMAN antibody
    • Akr1a1 antibody
    • Alcohol dehydrogenase [NADP+] antibody
    • Alcohol dehydrogenase antibody
    • Aldehyde reductase antibody
    • Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody
    • Aldo-keto reductase family 1 member A1 antibody
    • ALDR1 antibody
    • ALR antibody
    • ARM antibody
    • DD3 antibody
    • MGC12529 antibody
    • MGC1380 antibody
    see all

Images

  • All lanes : Anti-AKR1A1 antibody (ab125878) at 1/1000 dilution

    Lane 1 : A549 whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 37 kDa



    10% SDS PAGE

References

This product has been referenced in:

See 1 Publication for this product

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