Overview

  • Product name

    Anti-AKR1B10 antibody [EPR9767(B)]
    See all AKR1B10 primary antibodies
  • Description

    Rabbit monoclonal [EPR9767(B)] to AKR1B10
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cyt, ICC/IF, WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human AKR1B10 aa 300-400 (C terminal). The exact sequence is proprietary.

  • Positive control

    • A549 cells; Human small intestine and A549 cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab139685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

ICC/IF 1/100 - 1/250.
WB 1/1000 - 1/10000. Predicted molecular weight: 36 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
    • Tissue specificity

      Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
    • Sequence similarities

      Belongs to the aldo/keto reductase family.
    • Cellular localization

      Lysosome. Secreted. Secreted through a lysosome-mediated non-classical pathway.
    • Information by UniProt
    • Database links

    • Alternative names

      • AK1BA_HUMAN antibody
      • AKR1B10 antibody
      • AKR1B11 antibody
      • AKR1B12 antibody
      • Aldo keto reductase family 1 member B10 antibody
      • aldo keto reductase family 1 member B11 antibody
      • Aldo-keto reductase family 1 member B10 (aldose reductase) antibody
      • Aldo-keto reductase family 1 member B10 antibody
      • Aldo-keto reductase family 1 member B11 (aldose reductase-like) antibody
      • aldose reductase like 1 antibody
      • Aldose reductase like antibody
      • aldose reductase like peptide antibody
      • Aldose reductase related protein antibody
      • Aldose reductase-like antibody
      • Aldose reductase-related protein antibody
      • ALDRLn antibody
      • ARL 1 antibody
      • ARL-1 antibody
      • ARL1 antibody
      • ARL1 Human small intestine reductase antibody
      • ARP antibody
      • hARP antibody
      • HIS antibody
      • HSI antibody
      • SI reductase antibody
      • Small intestine reductase antibody
      see all

    Images

    • All lanes : Anti-AKR1B10 antibody [EPR9767(B)] (ab139685) at 1/1000 dilution

      Lane 1 : Human small intestine cell lysate
      Lane 2 : A549 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 36 kDa

    • Immunofluorescent analysis of A549 cells labeling AKR1B10 with ab139685 at 1/100 dilution.

    References

    This product has been referenced in:

    • Cong Z  et al. Long non-coding RNA linc00665 promotes lung adenocarcinoma progression and functions as ceRNA to regulate AKR1B10-ERK signaling by sponging miR-98. Cell Death Dis 10:84 (2019). Read more (PubMed: 30692511) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab139685.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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