Overview

  • Product name

  • Description

    Rabbit polyclonal to AKR1C3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human AKR1C3.
    Database link: P42330

  • Positive control

    • K562, Jurkat, HepG2, A549 and SW620 cell extracts; Human esophageal cancer, rat kidney and rat brain tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab196673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/500 - 1/2000. Predicted molecular weight: 37 kDa.

Target

  • Function

    Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
  • Tissue specificity

    Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
  • Sequence similarities

    Belongs to the aldo/keto reductase family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • 17 beta HSD 5 antibody
    • 17 beta hydroxysteroid dehydrogenase type 5 antibody
    • 17-beta-HSD 5 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 5 antibody
    • 2-dihydrobenzene-1 antibody
    • 2-diol dehydrogenase antibody
    • 20 alpha-hydroxysteroid dehydrogenase antibody
    • 20-alpha-hydroxysteroid dehydrogenase antibody
    • 3 alpha hydroxysteroid dehydrogenase type II antibody
    • 3-alpha-HSD type 2 antibody
    • 3-alpha-HSD type II antibody
    • 3-alpha-HSD type II, brain antibody
    • 3-alpha-hydroxysteroid dehydrogenase type 2 antibody
    • AK1C3_HUMAN antibody
    • AKR1 C3 antibody
    • Akr1c18 antibody
    • AKR1C3 antibody
    • Aldo keto reductase family 1 member C3 antibody
    • Aldo-keto reductase family 1 member C3 antibody
    • brain antibody
    • Chlordecone reductase antibody
    • Chlordecone reductase homolog HAKRb antibody
    • DD-3 antibody
    • DD3 antibody
    • DDH1 antibody
    • DDX antibody
    • Dihydrodiol dehydrogenase 3 antibody
    • Dihydrodiol dehydrogenase type I antibody
    • Dihydrodiol dehydrogenase X antibody
    • HA1753 antibody
    • HAKRB antibody
    • HAKRe antibody
    • hluPGFS antibody
    • HSD17B5 antibody
    • Indanol dehydrogenase antibody
    • KIAA0119 antibody
    • PGFS antibody
    • Prostaglandin F synthase antibody
    • Testosterone 17-beta-dehydrogenase 5 antibody
    • Trans-1 antibody
    • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase antibody
    • Type IIb 3 alpha hydroxysteroid dehydrogenase antibody
    see all

Images

  • All lanes : Anti-AKR1C3 antibody (ab196673) at 1/500 dilution

    Lane 1 : K562 cell extract
    Lane 2 : Jurkat cell extract
    Lane 3 : HepG2 cell extract
    Lane 4 : A549 cell extract
    Lane 5 : SW620 cell extract

    Predicted band size: 37 kDa

  • Immunohistochemical analysis of paraffin-embedded Human esophageal cancer tissue labeling AKR1C3 with ab196673 at 1/100 dilution.

  • Immunohistochemical analysis of paraffin-embedded rat kidney tissue labeling AKR1C3 with ab196673 at 1/100 dilution.

  • Immunohistochemical analysis of paraffin-embedded rat brain tissue labeling AKR1C3 with ab196673 at 1/100 dilution.

References

ab196673 has not yet been referenced specifically in any publications.

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