Anti-AKR1C4 antibody (ab197973)
Key features and details
- Rabbit polyclonal to AKR1C4
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-AKR1C4 antibody -
Description
Rabbit polyclonal to AKR1C4 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Recombinant full length protein corresponding to Human AKR1C4 aa 1 to the C-terminus. Full length fusion protein. The identity of the protein fusion partner is GST.
Database link: P17516 -
Positive control
- Mouse liver tissue lysate. Human liver cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab197973 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/200 - 1/1000. Predicted molecular weight: 37 kDa.
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IHC-P |
1/25 - 1/100.
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Notes |
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WB
1/200 - 1/1000. Predicted molecular weight: 37 kDa. |
IHC-P
1/25 - 1/100. |
Target
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Function
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. -
Tissue specificity
Liver specific. -
Sequence similarities
Belongs to the aldo/keto reductase family. -
Post-translational
modificationsThe N-terminus is blocked. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 1109 Human
- Entrez Gene: 83702 Mouse
- Entrez Gene: 307092 Rat
- Omim: 600451 Human
- SwissProt: P17516 Human
- SwissProt: P70694 Mouse
- Unigene: 567245 Human
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Alternative names
- 3 alpha HSD1 antibody
- 3-alpha-HSD1 antibody
- 3-alpha-hydroxysteroid dehydrogenase type I antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab197973 has not yet been referenced specifically in any publications.