Anti-AKR7A2 antibody (ab155528)
Key features and details
- Rabbit polyclonal to AKR7A2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AKR7A2 antibody
See all AKR7A2 primary antibodies -
Description
Rabbit polyclonal to AKR7A2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rat, Cow -
Immunogen
Recombinant fragment corresponding to a region within amino acids 172-359 of Human AKR7A2 (UniProt O43488).
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Positive control
- 293T, A431, Jurkat and Raji cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155528 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 40 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 40 kDa. |
Target
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Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. -
Tissue specificity
Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed. -
Sequence similarities
Belongs to the aldo/keto reductase 2 family. -
Cellular localization
Golgi apparatus. Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 511996 Cow
- Entrez Gene: 8574 Human
- Entrez Gene: 171445 Rat
- Omim: 603418 Human
- SwissProt: O43488 Human
- SwissProt: Q8CG45 Rat
- Unigene: 571886 Human
- Unigene: 8548 Rat
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Alternative names
- AFAR antibody
- AFAR1 antibody
- AFB1 aldehyde reductase 1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab155528 has been referenced in 1 publication.
- Chazarin B et al. Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos). Antioxidants (Basel) 8:N/A (2019). PubMed: 31443506