Recombinant
RabMAb

Recombinant Anti-AKT1 (phospho S473) antibody [EP2109Y] (ab81283)

Rabbit recombinant monoclonal AKT1 (phospho S473) antibody [EP2109Y]. Validated in WB, IHC, Dot, ICC/IF, In-Cell ELISA and tested in Mouse, Rat, Human. Cited in 198 publication(s).

Publishing research using ab81283? Please let us know so that we can cite the reference in this datasheet.

ab81283 has been referenced in 243 publications.

  • Wu D  et al. MicroRNA-17 promotes osteosarcoma cells proliferation and migration and inhibits apoptosis by regulating SASH1 expression. Pathol Res Pract 215:115-120 (2019). PubMed: 30396754
  • Wang G  et al. Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25-dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Exp Ther Med 17:679-688 (2019). PubMed: 30651850
  • Yuan YH  et al. Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Commun Signal 17:9 (2019). PubMed: 30683109
  • Wang L  et al. miR-122 and miR-199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway. Int J Mol Med 43:1373-1381 (2019). PubMed: 30664152
  • He J  et al. BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway. Aging (Albany NY) 11:350-370 (2019). PubMed: 30696802
  • Sun X  et al. Inhibition of NET-1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. Exp Ther Med 17:2334-2340 (2019). PubMed: 30867719
  • Yuan T  et al. Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncol Lett 17:3719-3726 (2019). PubMed: 30881494
  • Wang X  et al. GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway. Life Sci 226:22-32 (2019). PubMed: 30905784
  • Chen X  et al. Decoy receptor-3 regulates inflammation and apoptosis via PI3K/AKT signaling pathway in coronary heart disease. Exp Ther Med 17:2614-2622 (2019). PubMed: 30906453
  • Yang Z  et al. Baicalein improves glucose metabolism in insulin resistant HepG2 cells. Eur J Pharmacol 854:187-193 (2019). PubMed: 30970232
  • Imai T  et al. Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis. Cancer Sci 110:1317-1330 (2019). PubMed: 30767320
  • Li D  et al. Mg-Zn-Mn alloy extract induces the angiogenesis of human umbilical vein endothelial cells via FGF/FGFR signaling pathway. Biochem Biophys Res Commun 514:618-624 (2019). PubMed: 31076107
  • Li Y  et al. Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells. Nutr Cancer 71:1007-1018 (2019). PubMed: 31032633
  • Zhang Y  et al. Ailanthone up-regulates miR-449a to restrain acute myeloid leukemia cells growth, migration and invasion. Exp Mol Pathol 108:114-120 (2019). PubMed: 31002772
  • Zhu J  et al. NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer. EBioMedicine 43:238-252 (2019). PubMed: 31047858
  • Yu S  et al. Long noncoding RNA H19 promotes chemotherapy resistance in choriocarcinoma cells. J Cell Biochem N/A:N/A (2019). PubMed: 31020694
  • Guo C  et al. Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1a (SDF-1a). J Int Med Res 47:1264-1278 (2019). PubMed: 30727793
  • Durymanov M  et al. Subcutaneous Inoculation of 3D Pancreatic Cancer Spheroids Results in Development of Reproducible Stroma-Rich Tumors. Transl Oncol 12:180-189 (2019). PubMed: 30554606
  • Wang Y  et al. Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes. Front Physiol 10:167 (2019). PubMed: 30873046
  • Wang M  et al. Protective effects of Myrica rubra flavonoids against hypoxia/reoxygenation-induced cardiomyocyte injury via the regulation of the PI3K/Akt/GSK3ß pathway. Int J Mol Med 43:2133-2143 (2019). PubMed: 30864694
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  • Zhu T  et al. LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression. J Cell Mol Med N/A:N/A (2018). PubMed: 30515972
  • Duan P  et al. Opening of mitoKATP improves cardiac function and inhibits apoptosis via the AKT-Foxo1 signaling pathway in diabetic cardiomyopathy. Int J Mol Med 42:2709-2719 (2018). PubMed: 30132505
  • Jiang W  et al. Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF-1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase-3 signaling pathway in small cell lung cancer. Oncol Lett 16:6445-6457 (2018). PubMed: 30405782
  • Maidarti M  et al. Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response. Hum Reprod N/A:N/A (2018). PubMed: 30521029
  • Wang J  et al. Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy. J Mol Neurosci N/A:N/A (2018). PubMed: 29736818
  • Jin X  et al. Overexpression of retinoblastoma-binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3-kinase/protein kinase B pathway suppression. Mol Med Rep 18:1571-1581 (2018). PubMed: 29901205
  • Jin J  et al. miR-448 targets Rab2B and is pivotal in the suppression of pancreatic cancer. Oncol Rep 40:1379-1389 (2018). PubMed: 30015954
  • Zhu J  et al. Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy-dependent pathway in human synovial sarcoma cells. Oncol Rep 40:1927-1936 (2018). PubMed: 30066884
  • Liang W  et al. Protective effects of rutin on liver injury in type 2 diabetic db/db mice. Biomed Pharmacother 107:721-728 (2018). PubMed: 30138894
  • Wudtiwai B  et al. Alpha-mangostin, an active compound in Garcinia mangostana, abrogates anoikis-resistance in human hepatocellular carcinoma cells. Toxicol In Vitro 53:222-232 (2018). PubMed: 30195041
  • Tian Y  et al. CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4-activated MEK/ERK and PI3K/AKT pathways. Mol Med Rep 18:4374-4380 (2018). PubMed: 30221695
  • Liu Y  et al. Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. Int J Mol Med 42:3037-3046 (2018). PubMed: 30272367
  • Yang F  et al. Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells. Life Sci 213:149-157 (2018). PubMed: 30352240
  • Huang M  et al. Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell. BMC Gastroenterol 18:169 (2018). PubMed: 30400838
  • Ye L  et al. NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts. Bone Res 6:32 (2018). PubMed: 30455992
  • Liu H  et al. LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res 37:279 (2018). PubMed: 30463570
  • Xiang T  et al. Vasculogenic mimicry formation in EBV-associated epithelial malignancies. Nat Commun 9:5009 (2018). PubMed: 30479336
  • Jin YL  et al. Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway. Onco Targets Ther 11:8185-8195 (2018). PubMed: 30532558
  • Liu Y & Zhang Y Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells. Exp Mol Pathol 106:109-115 (2018). PubMed: 30594603
  • Zeng Q  et al. Inhibition of REDD1 Sensitizes Bladder Urothelial Carcinoma to Paclitaxel by Inhibiting Autophagy. Clin Cancer Res 24:445-459 (2018). PubMed: 29084921
  • Zhou Z  et al. Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia-reperfusion injury via upregulation of the PI3K/Akt pathway. Mol Med Rep 18:1560-1570 (2018). PubMed: 29901074
  • Yang P  et al. miR-140-5p regulates cell migration and invasion of non-small cell lung cancer cells through targeting VEGFA. Mol Med Rep 18:2866-2872 (2018). PubMed: 30015904
  • Zhao W  et al. Transcription factor ATF3 mediates the radioresistance of breast cancer. J Cell Mol Med 22:4664-4675 (2018). PubMed: 30117642
  • Wang Z  et al. Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma. Oncol Lett 16:3699-3705 (2018). PubMed: 30127980
  • Zhang Y  et al. Treatment with placental growth factor attenuates myocardial ischemia/reperfusion injury. PLoS One 13:e0202772 (2018). PubMed: 30212490
  • Hu N & Zhang H CYP24A1 depletion facilitates the antitumor effect of vitamin D3 on thyroid cancer cells. Exp Ther Med 16:2821-2830 (2018). PubMed: 30233662
  • Wang Y  et al. Guanidinoacetic Acid Regulates Myogenic Differentiation and Muscle Growth Through miR-133a-3p and miR-1a-3p Co-mediated Akt/mTOR/S6K Signaling Pathway. Int J Mol Sci 19:N/A (2018). PubMed: 30235878
  • Dai X  et al. Src kinase inhibitor PP2 regulates the biological characteristics of A549 cells via the PI3K/Akt signaling pathway. Oncol Lett 16:5059-5065 (2018). PubMed: 30250573
  • Zhang S  et al. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System. Stem Cells Int 2018:8478953 (2018). PubMed: 30363977
  • Lu Y  et al. Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs. Mol Ther Nucleic Acids 10:349-360 (2018). WB . PubMed: 29499946
  • Jiang Y  et al. TIPE2 governs macrophage polarization via negative regulation of mTORC1. Mol Med Rep 17:952-960 (2018). PubMed: 29115630
  • Wang S & Gu K Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of rapamycin signaling pathway. Mol Med Rep 17:2952-2956 (2018). PubMed: 29257307
  • Ye K  et al. Ang1/Tie2 induces cell proliferation and migration in human papillary thyroid carcinoma via the PI3K/AKT pathway. Oncol Lett 15:1313-1318 (2018). PubMed: 29387247
  • Lin Y  et al. Effects of combined radiosurgery and temozolomide therapy on epidermal growth factor receptor and variant III in glioblastoma multiforme. Oncol Lett 15:5751-5759 (2018). PubMed: 29563997
  • Chen Y  et al. Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. Cancer Sci 109:384-394 (2018). PubMed: 29197138
  • Tankiewicz-Kwedlo A  et al. Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer. Br J Pharmacol 175:743-762 (2018). IHC-P . PubMed: 29160911
  • He D  et al. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1. Redox Biol 15:228-242 (2018). WB ; Mouse . PubMed: 29277016
  • Liu W  et al. Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/ß-catenin signaling pathway. Cell Death Dis 9:343 (2018). PubMed: 29497056
  • Yang R  et al. Knockout of the placenta specific 8 gene radiosensitizes nasopharyngeal carcinoma cells by activating the PI3K/AKT/GSK3ß pathway. Am J Transl Res 10:455-464 (2018). PubMed: 29511439
  • Kovalchuk A  et al. Growth of Triple Negative and Progesterone Positive Breast Cancer Causes Oxidative Stress and Down-Regulates Neuroprotective Transcription Factor NPAS4 and NPAS4-Regulated Genes in Hippocampal Tissues of TumorGraft Mice-an Aging Connection. Front Genet 9:58 (2018). WB . PubMed: 29556248
  • Gu Y  et al. BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway. Int J Mol Med 41:2660-2668 (2018). PubMed: 29393377
  • Zhang B  et al. Metastasis-associated protein 2 promotes the metastasis of non-small cell lung carcinoma by regulating the ERK/AKT and VEGF signaling pathways. Mol Med Rep 17:4899-4908 (2018). PubMed: 29393472
  • Guo J  et al. Androgen receptor reverts dexamethasone-induced inhibition of prostate cancer cell proliferation and migration. Mol Med Rep 17:5887-5893 (2018). PubMed: 29436611
  • Yang XS  et al. Ouabain suppresses the growth and migration abilities of glioma U-87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF-1a. Mol Med Rep 17:5595-5600 (2018). PubMed: 29436645
  • Liu S & Liu B Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. Med Sci Monit 24:1424-1433 (2018). PubMed: 29519997
  • Luo J  et al. Elevated Expression of IRS-1 Associates with p-Akt Expression and Predicts Poor Prognosis of Breast Invasive Ductal Carcinoma. Hum Pathol N/A:N/A (2018). PubMed: 29551677
  • Zeng B  et al. SPP1 promotes ovarian cancer progression via Integrin ß1/FAK/AKT signaling pathway. Onco Targets Ther 11:1333-1343 (2018). PubMed: 29559792
  • Zhang J & Li Z ß-inducible gene-h3 promotes human breast carcinoma cell metastasis by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway. Exp Ther Med 15:2910-2916 (2018). PubMed: 29599830
  • Li N  et al. Effects of isoliquiritigenin on ovarian cancer cells. Onco Targets Ther 11:1633-1642 (2018). PubMed: 29606882
  • Prabakaran AD  et al. Identification of early indicators of altered metabolism in normal development using a rodent model system. Dis Model Mech 11:N/A (2018). PubMed: 29434026
  • Wang L  et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway. Mol Med Rep 17:7017-7026 (2018). PubMed: 29568863
  • Oldrini B  et al. Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling. Nat Commun 9:1466 (2018). PubMed: 29654229
  • Zhang Q  et al. PPAR? Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling. PPAR Res 2018:6970407 (2018). PubMed: 29686697
  • Hyrenius-Wittsten A  et al. De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nat Commun 9:1770 (2018). PubMed: 29720585
  • Jia Z  et al. miR-126 suppresses epithelial-to-mesenchymal transition and metastasis by targeting PI3K/AKT/Snail signaling of lung cancer cells. Oncol Lett 15:7369-7375 (2018). PubMed: 29725450
  • Liu S  et al. Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy. Oncol Lett 15:7707-7715 (2018). PubMed: 29740490
  • Zhou S  et al. Low expression of SEMA6C accelerates the primordial follicle activation in the neonatal mouse ovary. J Cell Mol Med 22:486-496 (2018). WB ; Mouse . PubMed: 28881413
  • zur Nedden S  et al. Protein kinase N1 critically regulates cerebellar development and long-term function. J Clin Invest 128:2076-2088 (2018). PubMed: 29494346
  • Ma W  et al. Induction of chemokine (C-C motif) ligand 5 by Epstein-Barr virus infection enhances tumor angiogenesis in nasopharyngeal carcinoma. Cancer Sci 109:1710-1722 (2018). PubMed: 29569795
  • Ding Q  et al. Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor-mediated angiogenesis. Int J Mol Med 42:171-181 (2018). PubMed: 29620150
  • Zhang Y  et al. PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. Oncol Lett 15:9069-9074 (2018). PubMed: 29805638
  • Li J  et al. Down-regulation of microRNA-27b promotes retinal pigment epithelial cell proliferation and migration by targeting Nox2. Pathol Res Pract 214:925-933 (2018). WB ; Human . PubMed: 29858119
  • Cao Y  et al. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. Eur J Pharmacol 827:215-226 (2018). Mouse . PubMed: 29551659
  • Cui Y & Yang S Overexpression of Annexin A1 protects against benzo[a]pyrene-induced bronchial epithelium injury. Mol Med Rep 18:349-357 (2018). PubMed: 29749523
  • Li L  et al. TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway. Cell Biol Int N/A:N/A (2018). PubMed: 29762880
  • Zheng Y  et al. Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. Cancer Lett 431:31-42 (2018). PubMed: 29807112
  • Sun J  et al. XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation. Oncogenesis 7:48 (2018). PubMed: 29910466
  • Liu F  et al. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3ß/ß-catenin signalling. J Exp Clin Cancer Res 37:122 (2018). PubMed: 29940988
  • Pan LY  et al. Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma. Drug Des Devel Ther 12:1941-1951 (2018). PubMed: 29983548
  • Xu H  et al. SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway. Onco Targets Ther 11:3775-3783 (2018). PubMed: 29997438
  • Chen W  et al. Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/ß-catenin signaling pathways. Cancer Manag Res 10:1817-1826 (2018). PubMed: 29997441
  • Wang Y  et al. Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway. Biomed Pharmacother 105:1172-1182 (2018). PubMed: 30021354
  • Rasheduzzaman M  et al. Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-?B signaling. Life Sci 208:208-220 (2018). PubMed: 30031063
  • Kamerkar S  et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature 546:498-503 (2017). IHC-P ; Human . PubMed: 28607485
  • Zhang B  et al. Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. Am J Cancer Res 7:1337-1349 (2017). WB ; Human . PubMed: 28670495
  • Wu CE  et al. Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. Exp Mol Med 49:e376 (2017). WB . PubMed: 28912571
  • Liang Z  et al. MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. Mol Cancer 16:96 (2017). WB ; Human . PubMed: 28549468
  • Yuan H  et al. FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells. J Exp Clin Cancer Res 36:72 (2017). PubMed: 28558758
  • Jin X  et al. HO-1/EBP interaction alleviates cholesterol-induced hypoxia through the activation of the AKT and Nrf2/mTOR pathways and inhibition of carbohydrate metabolism in cardiomyocytes. Int J Mol Med 39:1409-1420 (2017). PubMed: 28487965
  • Zhou W  et al. MicroRNA-138 inhibits hypoxia-induced proliferation of endothelial progenitor cells via inhibition of HIF-1a-mediated MAPK and AKT signaling. Exp Ther Med 13:1017-1024 (2017). WB ; Human . PubMed: 28450935
  • Yang L  et al. Total Flavonoids Extracted from Oxytropis falcata Bunge Improve Insulin Resistance through Regulation on the IKKß/NF-?B Inflammatory Pathway. Evid Based Complement Alternat Med 2017:2405124 (2017). WB ; Rat . PubMed: 28458712
  • Majumder P  et al. Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario. Dis Model Mech 10:655-669 (2017). PubMed: 28360125
  • El Gamal H  et al. Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury. Biomed Res Int 2017:5903105 (2017). WB . PubMed: 28386557
  • Jiang G  et al. Mediation of insulin growth factor-1 in Alzheimer's disease and the mechanism of PRNP genetic expression and the PI3K/Akt signaling pathway. Exp Ther Med 13:2763-2766 (2017). WB . PubMed: 28587338
  • Su W  et al. GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer. Oncotarget 8:4449-4459 (2017). PubMed: 27966458
  • Chen J  et al. AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway. Onco Targets Ther 10:811-817 (2017). WB . PubMed: 28243117
  • Chen Y  et al. Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. Oncol Lett 14:2125-2130 (2017). PubMed: 28781653
  • Chen X  et al. The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKß/AMPK pathways. Redox Biol 12:987-1003 (2017). PubMed: 28499253
  • Chen S  et al. Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways. Oncol Lett 14:4659-4662 (2017). WB ; Human . PubMed: 29085464
  • Kazi JU  et al. ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Oncotarget 8:12194-12202 (2017). Mouse . PubMed: 28086240
  • Cao Y  et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. PLoS One 12:e0186520 (2017). PubMed: 29140979
  • Moharram SA  et al. T-cell Acute Lymphoblastic Leukemia Cells Display Activation of Different Survival Pathways. J Cancer 8:4124 (2017). PubMed: 29187889
  • Su WJ  et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation 14:210 (2017). PubMed: 29084550
  • Yu W  et al. A nomogram based on phosphorylated AKT1 for predicting locoregional recurrence in patients with oesophageal squamous cell carcinoma. J Cancer 8:3755-3763 (2017). IHC-P ; Human . PubMed: 29151963
  • Rai SN  et al. Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson's Disease through NF-?B/pAKT Signaling Pathways. Front Aging Neurosci 9:421 (2017). PubMed: 29311905
  • Feng F  et al. Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes. Oncotarget 8:95332-95345 (2017). PubMed: 29221131
  • Shuang W  et al. Mcl-1 stabilization confers resistance to taxol in human gastric cancer. Oncotarget 8:82981-82990 (2017). PubMed: 29137317
  • Qian LQ  et al. Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway. Oncol Lett 14:4897-4905 (2017). PubMed: 29085498
  • Zeng X  et al. Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells. Oncotarget 8:72872-72885 (2017). PubMed: 29069832
  • Shinsuke K  et al. Chronic irradiation with low-dose-rate 137Cs-? rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation. J Radiat Res 58:809-815 (2017). PubMed: 29106600
  • Ke K & Lou T MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway. Oncol Lett 14:5994-6000 (2017). PubMed: 29113237
  • Diao S  et al. Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1a. Oncotarget 8:76770-76782 (2017). PubMed: 29100347
  • Chen X  et al. Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells. Sci Rep 7:13248 (2017). PubMed: 29038536
  • Liu Y  et al. The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway. Oncol Lett 13:4685-4690 (2017). PubMed: 28599470
  • Ding P  et al. CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells. Oncotarget 8:51151-51163 (2017). PubMed: 28881637
  • Zhang Y  et al. AGO2 involves the malignant phenotypes and FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells. Oncotarget 8:54735-54746 (2017). PubMed: 28903378
  • Yang L  et al. The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion. Exp Ther Med 14:2839-2844 (2017). PubMed: 28912846
  • Si F  et al. MicroRNA-138 suppresses cell proliferation in laryngeal squamous cell carcinoma via inhibiting EZH2 and PI3K/AKT signaling. Exp Ther Med 14:1967-1974 (2017). PubMed: 28962111
  • Liang Z  et al. SUMOylation of IQGAP1 promotes the development of colorectal cancer. Cancer Lett 411:90-99 (2017). PubMed: 28987385
  • Fang JF  et al. Upregulation of RASAL2 promotes proliferation and metastasis, and is targeted by miR-203 in hepatocellular carcinoma. Mol Med Rep 15:2720-2726 (2017). PubMed: 28447723
  • Liu L  et al. HMGA1 participates in MHCC97H cell proliferation and invasion through the ILK/Akt/GSK3ß signaling pathway. Mol Med Rep 16:9287-9294 (2017). PubMed: 29152644
  • Yang CY  et al. Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget 8:33756-33769 (2017). WB . PubMed: 28422711
  • Prakoura N  et al. NF?B-Induced Periostin Activates Integrin-ß3 Signaling to Promote Renal Injury in GN. J Am Soc Nephrol 28:1475-1490 (2017). PubMed: 27920156
  • Liu W  et al. A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism. Int J Oncol 50:1792-1800 (2017). PubMed: 28350132
  • Yang HH  et al. Protective Effects of MicroRNA-126 on Human Cardiac Microvascular Endothelial Cells Against Hypoxia/Reoxygenation-Induced Injury and Inflammatory Response by Activating PI3K/Akt/eNOS Signaling Pathway. Cell Physiol Biochem 42:506-518 (2017). PubMed: 28578351
  • Xiao Q  et al. Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Mol Med Rep 16:7520-7526 (2017). PubMed: 28944825
  • Yuan D  et al. Effect of integrin-linked kinase gene silencing on microRNA expression in ovarian cancer. Mol Med Rep 16:7267-7276 (2017). PubMed: 28944870
  • Bian H  et al. Beneficial effects of extracts from Lucilia sericata maggots on burn wounds in rats. Mol Med Rep 16:7213-7220 (2017). PubMed: 28944889
  • Belkaid A  et al. 17ß-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells. Carcinogenesis 38:402-410 (2017). PubMed: 28334272
  • Peng HB  et al. Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF-?B pathway in silicotic rats. Mol Med Rep 15:3121-3128 (2017). PubMed: 28350071
  • Zhang J  et al. Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells. Cell Death Dis 8:e2954 (2017). PubMed: 28749469
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