Alaproclate hydrochloride, serotonin uptake inhibitor (ab145917)

Overview

  • Product name

    Alaproclate hydrochloride, serotonin uptake inhibitor
  • Description

    Potent, selective serotonin uptake inhibitor. Potent, reversible, noncompetitive NMDA antagonist.
  • Biological description

    Potent, selective serotonin uptake inhibitor. Potent, reversible, noncompetitive NMDA antagonist (IC50 = 0.3 μM). Kv1.2 channel blocker (IC50 = 6.9 μM). Shows antidepressant effects in vivo.
  • Purity

    > 95%
  • CAS Number

    60719-83-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Svensson BE  et al. Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA. Neuropharmacology 33:795-804 (1994). Read more (PubMed: 7936117) »
  • Wilkinson A  et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow. J Pharmacol Exp Ther 271:1314-9 (1994). Read more (PubMed: 7996440) »
  • Danysz W  et al. Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs. Pharmacol Toxicol 62:42-50 (1988). Read more (PubMed: 2965810) »

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