• Product name

    Anti-ALDH4A1/P5CDH antibody
    See all ALDH4A1/P5CDH primary antibodies
  • Description

    Rabbit polyclonal to ALDH4A1/P5CDH
  • Host species

  • Specificity

    ab196612 detects endogenous level of total ALDH4A1/P5CDH protein.

  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human ALDH4A1/P5CDH (C terminal). The exact sequence is proprietary.
    Database link: P30038

  • Positive control

    • HepG2, K562, A469 and BT474 cell lysates; mouse skeletal muscle, intestine and kidney lysates. Human breast cancer, Human thyroid cancer and mouse lung tissues. A549 cells.
  • General notes

     This product was previously labelled as ALDH4A1




Our Abpromise guarantee covers the use of ab196612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/50 - 1/200. Predicted molecular weight: 62 kDa.
ICC/IF 1/50 - 1/200.


  • Function

    Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
  • Tissue specificity

    Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
  • Pathway

    Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.
  • Involvement in disease

    Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2) [MIM:239510]. HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.
  • Sequence similarities

    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • AL4A1_HUMAN antibody
    • aldehyde dehydrogenase 4 antibody
    • aldehyde dehydrogenase 4 family, member A1 antibody
    • Aldehyde dehydrogenase family 4 member A1 antibody
    • Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody
    • ALDH4 antibody
    • aldh4a1 antibody
    • Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody
    • Delta-1-pyrroline-5-carboxylate dehydrogenase antibody
    • L-glutamate gamma-semialdehyde dehydrogenase antibody
    • mitochondrial antibody
    • mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody
    • P5C dehydrogenase antibody
    • P5CD antibody
    • P5CDh antibody
    • P5CDhL antibody
    • P5CDhS antibody
    • Pyrroline-5-carboxylate dehydrogenase antibody
    • RP11 128M10.1 antibody
    see all


  • All lanes : Anti-ALDH4A1/P5CDH antibody (ab196612) at 1/500 dilution

    Lane 1 : HepG2 cell lysate
    Lane 2 : K562 cell lysate
    Lane 3 : A549 cell lysate
    Lane 4 : BT474 cell lysate
    Lane 5 : mouse skeletal muscle lysate
    Lane 6 : mouse intestine lysate
    Lane 7 : mouse kidney lysate

    Predicted band size: 62 kDa

  • Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling ALDH4A1/P5CDH using ab196612 at a 1/200 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ALDH4A1/P5CDH using ab196612 at a 1/200 dilution.

  • Immunohistochemical analysis of paraffin-embedded mouse lung tissue labeling ALDH4A1/P5CDH using ab196612 at a 1/200 dilution.

  • Immunofluorescence analysis of A549 cells, labeling ALDH4A1/P5CDH using ab196612 at a 1/50 dilution.


ab196612 has not yet been referenced specifically in any publications.

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