Overview

  • Product name

    Anti-ALDH5A1/SSADH antibody (Biotin)
    See all ALDH5A1/SSADH primary antibodies
  • Description

    Goat polyclonal to ALDH5A1/SSADH (Biotin)
  • Host species

    Goat
  • Conjugation

    Biotin
  • Specificity

    This antibody is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1). Amino acid numbering in name calculated from NP_733936.1.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human ALDH5A1/SSADH aa 485-496 (internal sequence) (Cysteine residue). (NP_733936.1).
    Sequence:

    C-SQDPAQIWRVAE


    Database link: P51649-2

  • Positive control

    • WB: Human liver lysate.
  • General notes

     This product was previously labelled as ALDH5A1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab239213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 57 kDa).

Target

  • Function

    Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificity

    Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • Pathway

    Amino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in disease

    Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similarities

    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • Aldedehyde dehydrogenase 5 family antibody
    • Aldehyde dehydrogenase 5 family member A1 antibody
    • Aldehyde dehydrogenase 5A1 antibody
    • Aldehyde dehydrogenase family 5 member A1 antibody
    • ALDH5A 1 antibody
    • Aldh5a1 antibody
    • mitochondrial antibody
    • Mitochondrial succinate semialdehyde dehydrogenase antibody
    • NAD(+) dependent succinic semialdehyde dehydrogenase antibody
    • NAD(+)-dependent succinic semialdehyde dehydrogenase antibody
    • SSADH antibody
    • SSDH antibody
    • SSDH_HUMAN antibody
    • Succinate semialdehyde dehydrogenase antibody
    • Succinate-semialdehyde dehydrogenase antibody
    see all

Images

  • Anti-ALDH5A1/SSADH antibody (Biotin) (ab239213) at 0.5 µg/ml + Human liver lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 57 kDa



    Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.

References

ab239213 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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