Overview

  • Product name

    Anti-ALDH6A1 antibody
  • Description

    Rabbit polyclonal to ALDH6A1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment within Human ALDH6A1 (internal sequence). The exact sequence is proprietary.
    Database link: Q02252

  • Positive control

    • WB: Mouse liver tissue whole cell lysate; HepG2 whole cell lysate. IHC-P: Mouse stomach tissue; human liver carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab228584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
  • Involvement in disease

    Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDH deficiency) [MIM:603178]. This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
  • Sequence similarities

    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1110038I05Rik antibody
    • AI314632 antibody
    • Aldehyde dehydrogenase 6 family member A1 antibody
    • Aldehyde dehydrogenase family 6 member A1 antibody
    • Aldehyde dehydrogenase family 6, subfamily A1 antibody
    • ALDH6A1 antibody
    • Malonate semialdehyde dehydrogenase antibody
    • Malonate-semialdehyde dehydrogenase [acylating] antibody
    • Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial antibody
    • Methylmalonate-semialdehyde dehydrogenase [acylating] antibody
    • MGC37325 antibody
    • MGC40271 antibody
    • Mitochondrial acylating methylmalonate semialdehyde dehydrogenase antibody
    • mitochondrial antibody
    • MMSA_HUMAN antibody
    • MMSADHA antibody
    • MMSDH antibody
    see all

Images

  • Paraffin-embedded mouse stomach tissue stained for ALDH6A1 with ab228584 at 1/500 dilution in immunohistochemical analysis.

  • Anti-ALDH6A1 antibody (ab228584) at 1/1000 dilution + Mouse liver tissue whole cell lysate at 50 µg

    Developed using the ECL technique.

    Predicted band size: 58 kDa



    7.5% SDS-PAGE

  • Anti-ALDH6A1 antibody (ab228584) at 1/500 dilution + HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 58 kDa



    7.5% SDS-PAGE

  • Paraffin-embedded human liver carcinoma tissue stained for ALDH6A1 with ab228584 at 1/250 dilution in immunohistochemical analysis.

References

ab228584 has not yet been referenced specifically in any publications.

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