Key features and details
- Rabbit polyclonal to Aldosterone 3
- Suitable for: RIA
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-Aldosterone 3 antibody
DescriptionRabbit polyclonal to Aldosterone 3
SpecificityCross Reactivity: 11- Deoxycorticosterone 1.1% Estradiol < 0.001% 11- Deoxycortisol < 0.001% Androsterone < 0.001% 21- Deoxycortisol < 0.001% Estriol < 0.001% Cortisone < 0.001% Estrone < 0.001% Testosterone < 0.01% Dihydrotesterone < 0.001%
Tested applicationsSuitable for: RIAmore details
Species reactivityReacts with: Species independent
Chemical/ Small Molecule conjugated to BSA: Aldosterone-3-BSA
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store In the Dark.
Storage bufferConstituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab49947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Note: 300,000 tests per ml by RIA.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceThe major mineralcorticoid, which is secreted almost independently of ACTH from the pitutitary, is aldosterone. Aldosterone secretion is controlled mostly by the levels of potassium and sodium in serum and a blood pressure control system called the renin-angiotensin system. The principle action of aldosterone is the retention of sodium. Where sodium goes, so goes associated ions and water. Therefore, aldosterone profoundly effects fluid balance by effecting intracellular and extracellular fluid volume. Aldosterone has the opposite effect on serum levels of potassium as it is lost in the urine in exchange for sodium in the renal tubules. Salivary and sweat glands are also influenced by aldosterone to save sodium and the intestine increases the absorption of sodium in response to aldosterone. Aldosterone levels increase and cause fluid retention in diseases such as congestive heart failure and liver cirrhosis. Certain diuretics act by antagonizing aldosterone. In contrast to most diuretics that cause potassium loss, the aldosterone antagonists increase blood potassium and are sometimes used for this effect.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab49947 has not yet been referenced specifically in any publications.