Overview

  • Product name

    Anti-Aldosterone 3 antibody
  • Description

    Rabbit polyclonal to Aldosterone 3
  • Host species

    Rabbit
  • Specificity

    Cross Reactivity: 11- Deoxycorticosterone 1.1% Estradiol < 0.001% 11- Deoxycortisol < 0.001% Androsterone < 0.001% 21- Deoxycortisol < 0.001% Estriol < 0.001% Cortisone < 0.001% Estrone < 0.001% Testosterone < 0.01% Dihydrotesterone < 0.001%
  • Tested applications

    Suitable for: RIAmore details
  • Species reactivity

    Reacts with: Species independent
  • Immunogen

    Chemical/ Small Molecule conjugated to BSA: Aldosterone-3-BSA

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store In the Dark.
  • Storage buffer

    Constituent: Whole serum
  • Purity

    Whole antiserum
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab49947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
RIA
  • Application notes
    RIA: Use at an assay dependent dilution.
    Note: 300,000 tests per ml by RIA.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance

      The major mineralcorticoid, which is secreted almost independently of ACTH from the pitutitary, is aldosterone. Aldosterone secretion is controlled mostly by the levels of potassium and sodium in serum and a blood pressure control system called the renin-angiotensin system. The principle action of aldosterone is the retention of sodium. Where sodium goes, so goes associated ions and water. Therefore, aldosterone profoundly effects fluid balance by effecting intracellular and extracellular fluid volume. Aldosterone has the opposite effect on serum levels of potassium as it is lost in the urine in exchange for sodium in the renal tubules. Salivary and sweat glands are also influenced by aldosterone to save sodium and the intestine increases the absorption of sodium in response to aldosterone. Aldosterone levels increase and cause fluid retention in diseases such as congestive heart failure and liver cirrhosis. Certain diuretics act by antagonizing aldosterone. In contrast to most diuretics that cause potassium loss, the aldosterone antagonists increase blood potassium and are sometimes used for this effect.

    References

    ab49947 has not yet been referenced specifically in any publications.

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