Alendronate monosodium trihydrate, bone resorption inhibitor (ab141897)

Overview

  • Product name

    Alendronate monosodium trihydrate, bone resorption inhibitor
  • Description

    Potent bone resorption inhibitor
  • Biological description

    Potent bone resorption inhibitor. Inhibits farnesyl synthase (IC50 = 460 nM) and the isoprenoid biosynthesis pathway. Able to increase TGF-β1 levels. Active in vivo and in vitro.
  • CAS Number

    121268-17-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    P,P'-(4-Amino-1-hydroxybutylidene)bisphosphonic acid sodium salt trihydrate
  • Molecular weight

    325.08
  • Molecular formula

    C4H12NNaO7P2.3H2O
  • PubChem identifier

    23681107
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jia J  et al. Prolonged alendronate treatment prevents the decline in serum TGF-ß1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model. Bone 52:424-32 (2013). Read more (PubMed: 23088940) »
  • Pytlik M  et al. Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats. Pharmacol Rep 64:625-34 (2012). Read more (PubMed: 22814016) »
  • Bergstrom JD  et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys 373:231-41 (2000). Read more (PubMed: 10620343) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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