Alexa Fluor® 488 Anti-CD34 antibody [4H11], prediluted (ab187568)

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Key features and details

  • Alexa Fluor® 488 Mouse monoclonal [4H11] to CD34, prediluted
  • Reacts with: Human
  • Conjugation: Alexa Fluor® 488. Ex: 495nm, Em: 519nm
  • Isotype: IgG1

Overview

  • Product name

    Alexa Fluor® 488 Anti-CD34 antibody [4H11], prediluted
    See all CD34 primary antibodies

  • Description

    Alexa Fluor® 488 Mouse monoclonal [4H11] to CD34, prediluted

  • Host species

    Mouse

  • Conjugation

    Alexa Fluor® 488. Ex: 495nm, Em: 519nm

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Tissue, cells or virus corresponding to Human CD34. Permanent Human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.

  • Epitope

    ab187568 reacts with Class III epitope on CD34.

  • Positive control

    • Kg-1a Human acute myelogenous leukemia cell line; Human chronic myeloid leukemia cell line MOLM-7

  • General notes

    ab187568 completely blocks binding of Class II antibody QBEnd10 and Class III antibodies BIRMA K3 and 8G12 on KG1a cell line.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

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Properties

Target

  • Function

    Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

  • Tissue specificity

    Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

  • Sequence similarities

    Belongs to the CD34 family.

  • Developmental stage

    On early hematopoietic progenitor cells.

  • Post-translational
    modifications

    Highly glycosylated.
    Phosphorylated on serine residues by PKC.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD34 antibody
      • CD34 antigen antibody
      • CD34 molecule antibody
      • CD34_HUMAN antibody
      • Cluster designation 34 antibody
      • cluster of differentiation 34 antibody
      • Hematopoietic progenitor cell antigen CD34 antibody
      • HPCA1 antibody
      • Mucosialin antibody
      • OTTHUMP00000034733 antibody
      • OTTHUMP00000034734 antibody
      see all

    References (0)

    Publishing research using ab187568? Please let us know so that we can cite the reference in this datasheet.

    ab187568 has not yet been referenced specifically in any publications.

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