Alexa Fluor® 488 Anti-FOXP3 antibody [3G3] (ab187598)

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Flow Cytometry - Alexa Fluor® 488 Anti-FOXP3 antibody [3G3] (ab187598)

    Key features and details

    • Alexa Fluor® 488 Mouse monoclonal [3G3] to FOXP3
    • Suitable for: Flow Cyt
    • Reacts with: Mouse, Human
    • Conjugation: Alexa Fluor® 488. Ex: 495nm, Em: 519nm
    • Isotype: IgG1

    Overview

    • Product name

      Alexa Fluor® 488 Anti-FOXP3 antibody [3G3]
      See all FOXP3 primary antibodies

    • Description

      Alexa Fluor® 488 Mouse monoclonal [3G3] to FOXP3

    • Host species

      Mouse

    • Conjugation

      Alexa Fluor® 488. Ex: 495nm, Em: 519nm

    • Tested applications

      Suitable for: Flow Cytmore details

    • Species reactivity

      Reacts with: Mouse, Human

    • Immunogen

      Recombinant full length protein (His-tag) corresponding to Mouse FOXP3 aa 1-429.
      Sequence:

      MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDL RSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPH FMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPP GINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKW PGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKE KLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREA PDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAI LEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVES EKGAVWTVDEFEFRKKRSQRPNKCSNPCP


      Database link: Q99JB6
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab187598 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt Use a concentration of 4 µg/ml.

    ab171463 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

     

    Target

    • Function

      Probable transcription factor. Plays a critical role in the control of immune response.

    • Involvement in disease

      Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

    • Sequence similarities

      Contains 1 C2H2-type zinc finger.
      Contains 1 fork-head DNA-binding domain.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    • Database links

      • Alternative names

        • AIID antibody
        • DIETER antibody
        • Forkhead box P3 antibody
        • Forkhead box protein P3 antibody
        • FOXP3 antibody
        • FOXP3_HUMAN antibody
        • FOXP3delta7 antibody
        • Immune dysregulation polyendocrinopathy enteropathy X linked antibody
        • Immunodeficiency polyendocrinopathy enteropathy X linked antibody
        • IPEX antibody
        • JM2 antibody
        • MGC141961 antibody
        • MGC141963 antibody
        • OTTHUMP00000025832 antibody
        • OTTHUMP00000025833 antibody
        • OTTHUMP00000226737 antibody
        • PIDX antibody
        • Scurfin antibody
        • XPID antibody
        see all

      Images

      • Flow Cytometry - Alexa Fluor® 488 Anti-FOXP3 antibody [3G3] (ab187598)
        Flow Cytometry - Alexa Fluor® 488 Anti-FOXP3 antibody [3G3] (ab187598)

        Intracellular staining of human peripheral blood cells (gated on CD4+ cells) with ab187598

      References (0)

      Publishing research using ab187598? Please let us know so that we can cite the reference in this datasheet.

      ab187598 has not yet been referenced specifically in any publications.

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