For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

We use cookies to make our site as useful as possible.

Our Cookie Policy explains how you can opt-out of the cookies we use.

If you continue without changing your cookie settings, we'll assume you’re happy with this.

Continue Continue

United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Diagnostic & Therapeutic Solutions
    Custom solutions & partnerships

    Custom antibody development and commercial partnerships to advance your diagnostic and therapeutic discovery.

    Create custom solutions with us

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Supporting our customers and employees during the COVID-19 pandemic. Read more

  1. Link

    alexa-fluor-647-beta-2-microglobulin-antibody-b2m01-ab187602.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Cardiovascular Blood Serum Proteins
Share by email

Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

  • Datasheet
  • SDS
Submit a review Submit a question

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

    Key features and details

    • Alexa Fluor® 647 Mouse monoclonal [B2M01] to beta 2 Microglobulin
    • Suitable for: ICC/IF
    • Reacts with: Human, Recombinant fragment
    • Conjugation: Alexa Fluor® 647. Ex: 652nm, Em: 668nm
    • Isotype: IgG2a

    You may also be interested in

    Primary
    Product image
    Anti-beta 2 Microglobulin antibody [EPR21752-214] - BSA and Azide free (ab237032)
    Knockout
    Product image
    Human B2M (beta 2 Microglobulin) knockout Hep G2 cell line (ab262325)
    Primary
    Product image
    Anti-Transferrin antibody (ab82411)

    View more associated products

    Overview

    • Product name

      Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01]
      See all beta 2 Microglobulin primary antibodies
    • Description

      Alexa Fluor® 647 Mouse monoclonal [B2M01] to beta 2 Microglobulin
    • Host species

      Mouse
    • Conjugation

      Alexa Fluor® 647. Ex: 652nm, Em: 668nm
    • Specificity

      ab187602 reacts with beta 2 microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta 2 microglobulin.
    • Tested Applications & Species

      Application Species
      IHC-P
      Recombinant fragment
      See all applications and species data
    • Immunogen

      Full length native protein (purified) corresponding to Human beta 2 Microglobulin.
      Database link: P61769

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C. Store In the Dark.
    • Storage buffer

      pH: 7.40
      Preservative: 0.097% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Size exclusion
    • Clonality

      Monoclonal
    • Clone number

      B2M01
    • Isotype

      IgG2a
    • Research areas

      • Cardiovascular
      • Blood
      • Serum Proteins
      • Cancer
      • Tumor biomarkers
      • Globulins
      • Cardiovascular
      • Blood
      • Blood Cell Antigens
      • WBC Antigens
      • HLA

    Associated products

    • Recombinant Protein

      • Recombinant Human beta 2 Microglobulin protein (ab98116)
    • Related Products

      • Recombinant Human beta 2 Microglobulin protein (ab151631)
      • Recombinant Human beta 2 Microglobulin protein (ab98116)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab187602 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Recombinant fragment
    Application Abreviews Notes
    ICC/IF
    Use at an assay dependent concentration.
    Notes
    ICC/IF
    Use at an assay dependent concentration.

    Target

    • Function

      Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
    • Involvement in disease

      Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
      Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
    • Sequence similarities

      Belongs to the beta-2-microglobulin family.
      Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
    • Post-translational
      modifications

      Glycation of Ile-21 is observed in long-term hemodialysis patients.
    • Cellular localization

      Secreted. Detected in serum and urine.
    • Target information above from: UniProt accession P61769 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 567 Human
      • Omim: 109700 Human
      • SwissProt: P61769 Human
      • Unigene: 534255 Human
      • Unigene: 702947 Human
      • Alternative names

        • B2M antibody
        • B2MG_HUMAN antibody
        • Beta 2 microglobin antibody
        • Beta 2 microglobulin antibody
        • Beta 2 microglobulin precursor antibody
        • Beta chain of mhc class 1 proteins antibody
        • Beta chain of MHC class I molecules antibody
        • Beta-2-microglobulin form pI 5.3 antibody
        • CDABP0092 antibody
        • Hdcma22p antibody
        • IMD43 antibody
        see all

      Images

      • Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)
        Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

        Immunocytochemistry/ Immunofluorescence of Human beta 2 Microglobulin-transfected canine cells labeled A)  with ab187602 and B) with Alexa Fluor® 647 conjugated Mouse IgG2a Isotype Control. Cells were fixed with 4% PFA and permeabilized with 0.1% PBS-Tween20 containing 2% BSA. Antibody concentration 2µg/ml.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab187602? Please let us know so that we can cite the reference in this datasheet.

      ab187602 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      There are currently no Customer reviews or Questions for ab187602.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

      Get resources and offers direct to your inbox Sign up
      A-Z by research area
      • Cancer
      • Cardiovascular
      • Cell biology
      • Developmental biology
      • Epigenetics & Nuclear signaling
      • Immunology
      • Metabolism
      • Microbiology
      • Neuroscience
      • Signal transduction
      • Stem cells
      A-Z by product type
      • Primary antibodies
      • Secondary antibodies
      • Biochemicals
      • Isotype controls
      • Flow cytometry multi-color selector
      • Kits
      • Loading controls
      • Lysates
      • Peptides
      • Proteins
      • Slides
      • Tags and cell markers
      • Tools & Reagents
      Help & support
      • Support
      • Make an Inquiry
      • Protocols & troubleshooting
      • Placing an order
      • RabMAb products
      • Biochemical product FAQs
      • Training
      • Browse by Target
      Company
      • Corporate site
      • Investor relations
      • Company news
      • Careers
      • About us
      • Blog
      Events
      • Tradeshows
      • Conferences
      International websites
      • abcam.cn
      • abcam.co.jp

      Join with us

      • LinkedIn
      • facebook
      • Twitter
      • YouTube
      • Terms of sale
      • Website terms of use
      • Cookie policy
      • Privacy policy
      • Legal
      • Modern slavery statement
      © 1998-2021 Abcam plc. All rights reserved.