Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

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Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

    Key features and details

    • Alexa Fluor® 647 Mouse monoclonal [B2M01] to beta 2 Microglobulin
    • Suitable for: ICC/IF
    • Reacts with: Human
    • Conjugation: Alexa Fluor® 647. Ex: 652nm, Em: 668nm
    • Isotype: IgG2a

    Overview

    • Product name

      Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01]
      See all beta 2 Microglobulin primary antibodies

    • Description

      Alexa Fluor® 647 Mouse monoclonal [B2M01] to beta 2 Microglobulin

    • Host species

      Mouse

    • Conjugation

      Alexa Fluor® 647. Ex: 652nm, Em: 668nm

    • Specificity

      ab187602 reacts with beta 2 microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta 2 microglobulin.

    • Tested applications

      Suitable for: ICC/IFmore details

    • Species reactivity

      Reacts with: Human
      Does not react with: Mouse, Rabbit, Chicken, Cow, Dog

    • Immunogen

      Full length native protein (purified) corresponding to Human beta 2 Microglobulin.
      Database link: P61769

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab187602 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    ICC/IF Use at an assay dependent concentration.

    Target

    • Function

      Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    • Involvement in disease

      Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
      Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

    • Sequence similarities

      Belongs to the beta-2-microglobulin family.
      Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

    • Post-translational
      modifications

      Glycation of Ile-21 is observed in long-term hemodialysis patients.

    • Cellular localization

      Secreted. Detected in serum and urine.
    • Information by UniProt

    • Database links

      • Alternative names

        • B2M antibody
        • B2MG_HUMAN antibody
        • Beta 2 microglobin antibody
        • Beta 2 microglobulin antibody
        • Beta 2 microglobulin precursor antibody
        • Beta chain of mhc class 1 proteins antibody
        • Beta chain of MHC class I molecules antibody
        • Beta-2-microglobulin form pI 5.3 antibody
        • CDABP0092 antibody
        • Hdcma22p antibody
        • IMD43 antibody
        see all

      Images

      • Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)
        Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-beta 2 Microglobulin antibody [B2M01] (ab187602)

        Immunocytochemistry/ Immunofluorescence of Human beta 2 Microglobulin-transfected canine cells labeled A)  with ab187602 and B) with Alexa Fluor® 647 conjugated Mouse IgG2a Isotype Control. Cells were fixed with 4% PFA and permeabilized with 0.1% PBS-Tween20 containing 2% BSA. Antibody concentration 2µg/ml.

      References (0)

      Publishing research using ab187602? Please let us know so that we can cite the reference in this datasheet.

      ab187602 has not yet been referenced specifically in any publications.

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