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Cell Biology Apoptosis Receptors Decoy Receptors
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Alexa Fluor® 647 Anti-DcR2 antibody [TRAIL-R4-01] (ab243076)

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Flow Cytometry - Alexa Fluor® 647 Anti-DcR2 antibody [TRAIL-R4-01] (ab243076)

    Key features and details

    • Alexa Fluor® 647 Mouse monoclonal [TRAIL-R4-01] to DcR2
    • Suitable for: Flow Cyt
    • Conjugation: Alexa Fluor® 647. Ex: 652nm, Em: 668nm
    • Isotype: IgG1

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    Overview

    • Product name

      Alexa Fluor® 647 Anti-DcR2 antibody [TRAIL-R4-01]
      See all DcR2 primary antibodies
    • Description

      Alexa Fluor® 647 Mouse monoclonal [TRAIL-R4-01] to DcR2
    • Host species

      Mouse
    • Conjugation

      Alexa Fluor® 647. Ex: 652nm, Em: 668nm
    • Tested applications

      Suitable for: Flow Cytmore details
    • Immunogen

      Recombinant fragment corresponding to Human DcR2 aa 1-250. Fused to hIgGhc.
      Database link: Q9UBN6

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Flow Cyt: DcR2-transfectants.
    • General notes

      Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C. Store In the Dark.
    • Storage buffer

      pH: 7.40
      Preservative: 0.0975% Sodium azide
      Constituent: PBS
    • Concentration information loading...
    • Purity

      Size exclusion
    • Purification notes

      Purified antibody is conjugated with Alexa Fluor® 647 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
    • Clonality

      Monoclonal
    • Clone number

      TRAIL-R4-01
    • Isotype

      IgG1
    • Research areas

      • Cell Biology
      • Apoptosis
      • Receptors
      • Decoy Receptors
      • Immunology
      • Innate Immunity
      • Cytokines
      • Necrosis Factors
      • Cancer
      • Invasion/microenvironment
      • Apoptosis
      • Death receptors & ligands
      • TRAIL
      • Cancer
      • Cell Death
      • Apoptosis
      • Receptors
      • Death receptors & ligands
      • TRAIL
      • Cancer
      • Cell Death
      • Apoptosis
      • Receptors
      • Decoy Receptors

    Associated products

      Applications

      The Abpromise guarantee

      Our Abpromise guarantee covers the use of ab243076 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      Application Abreviews Notes
      Flow Cyt
      Use at an assay dependent concentration.
      Notes
      Flow Cyt
      Use at an assay dependent concentration.

      Target

      • Function

        Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
      • Tissue specificity

        Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
      • Sequence similarities

        Contains 1 death domain.
        Contains 3 TNFR-Cys repeats.
      • Cellular localization

        Membrane.
      • Target information above from: UniProt accession Q9UBN6 The UniProt Consortium
        The Universal Protein Resource (UniProt) in 2010
        Nucleic Acids Res. 38:D142-D148 (2010) .

        Information by UniProt
      • Alternative names

        • CD 264 antibody
        • CD264 antibody
        • DcR 2 antibody
        • DcR2 antibody
        • Decoy receptor 2 antibody
        • Decoy with truncated death domain antibody
        • OTTHUMP00000123528 antibody
        • TNF receptor related receptor for TRAIL antibody
        • TNF related apoptosis inducing ligand receptor 4 antibody
        • TNF-related apoptosis-inducing ligand receptor 4 antibody
        • TNFRSF 10D antibody
        • TNFRSF10D antibody
        • TR10D_HUMAN antibody
        • TRAIL R4 antibody
        • TRAIL receptor 4 antibody
        • TRAIL receptor with a truncated death domain antibody
        • TRAIL-R4 antibody
        • TRAILR4 antibody
        • TRUNDD antibody
        • Tumor necrosis factor receptor superfamily member 10D antibody
        • Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain antibody
        see all

      Images

      • Flow Cytometry - Alexa Fluor® 647 Anti-DcR2 antibody [TRAIL-R4-01] (ab243076)
        Flow Cytometry - Alexa Fluor® 647 Anti-DcR2 antibody [TRAIL-R4-01] (ab243076)

        Flow cytometric analysis of DcR2-transfectants labeling DcR2 with ab243076.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab243076? Please let us know so that we can cite the reference in this datasheet.

      ab243076 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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