Storage instructionsShipped at 4°C. Store at -20°C.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 69% PBS, 30% Glycerol, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
Our Abpromise guarantee covers the use of ab155935 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/5000. Predicted molecular weight: 112 kDa.|
FunctionParticipates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
PathwayProtein modification; protein glycosylation.
Involvement in diseaseDefects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) [MIM:608540]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Sequence similaritiesBelongs to the glycosyltransferase 1 family.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- 4-mannosyltransferase antibody
- Alg1 antibody
- ALG1_HUMAN antibody
All lanes : Anti-ALG1 antibody (ab155935) at 1/5000 dilution
Lane 1 : Wild type Caenorhabditis elegans extract
Lane 2 : ALG1 negative (-) Caenorhabditis elegans extract
Lysates/proteins at 15 µg per lane.
All lanes : Goat anti-rabbit HRP conjugated antibody at 1/15000 dilution
Predicted band size: 112 kDa
4-20% Tris-HCl polyacrylamide gel.
ab155935 has not yet been referenced specifically in any publications.