Recombinant Anti-ALG2 antibody [EPR12006(2)(B)] (ab178697)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR12006(2)(B)] to ALG2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-ALG2 antibody [EPR12006(2)(B)]
See all ALG2 primary antibodies -
Description
Rabbit monoclonal [EPR12006(2)(B)] to ALG2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human ALG2 aa 1-100 (Cysteine residue). The exact sequence is proprietary.
Database link: Q9H553 -
Positive control
- HepG2, HeLa, A431 and Human fetal kidney lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR12006(2)(B) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab178697 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/10000 - 1/50000. Predicted molecular weight: 47 kDa.
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Notes |
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WB
1/10000 - 1/50000. Predicted molecular weight: 47 kDa. |
Target
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Function
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. -
Pathway
Protein modification; protein glycosylation. -
Involvement in disease
Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I) [MIM:607906]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. -
Sequence similarities
Belongs to the glycosyltransferase 1 family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 85365 Human
- Omim: 607905 Human
- SwissProt: Q9H553 Human
- Unigene: 40919 Human
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Alternative names
- 3-mannosyltransferase ALG2 antibody
- ALG2 alpha-1,3/1,6-mannosyltransferase antibody
- ALG2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab178697 has not yet been referenced specifically in any publications.