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Cardiovascular Angiogenesis Growth Factors TGF
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Anti-ALK-1 antibody (ab10179)

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Western blot - Anti-ALK-1 antibody (ab10179)

    Key features and details

    • Goat polyclonal to ALK-1
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    View more associated products

    Overview

    • Product name

      Anti-ALK-1 antibody
      See all ALK-1 primary antibodies
    • Description

      Goat polyclonal to ALK-1
    • Host species

      Goat
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide within Human ALK-1 aa 450 to the C-terminus (Cysteine residue). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Lung and liver extracts.
    • General notes

      Activin A receptor, type II-like 1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376 ) also known as Rendu-Osler-Weber syndrome 2 (ORW2). Note: ACVRL1 is also known as ALK1 - not to be confused with the similarly named ALK (anaplastic lymphoma kinase).

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      pH: 7.3
      Preservative: 0.02% Sodium azide
      Constituents: Tris buffered saline, 0.5% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    • Primary antibody notes

      Activin A receptor, type II-like 1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376 ) also known as Rendu-Osler-Weber syndrome 2 (ORW2). Note: ACVRL1 is also known as ALK1 - not to be confused with the similarly named ALK (anaplastic lymphoma kinase).
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cardiovascular
      • Angiogenesis
      • Growth Factors
      • TGF
      • Signal Transduction
      • Metabolism
      • Amino Acids
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • Other Kinases
      • Signal Transduction
      • Growth Factors/Hormones
      • TGF
      • Cardiovascular
      • Vasculature
      • Endothelium
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Amino acid metabolism
      • Metabolism
      • Types of disease
      • Cancer

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Recombinant Protein

      • Recombinant human ALK-1 protein (ab70317)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab10179 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    Application Abreviews Notes
    WB
    Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa).

    1 hour primary incubation is recommended for this product.

    Notes
    WB
    Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa).

    1 hour primary incubation is recommended for this product.

    Target

    • Function

      On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
    • Involvement in disease

      Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
    • Sequence similarities

      Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P37023 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 94 Human
      • Omim: 601284 Human
      • SwissProt: P37023 Human
      • Unigene: 591026 Human
      • Alternative names

        • Activin A receptor antibody
        • Activin A receptor type II like 1 antibody
        • Activin A receptor, type II like kinase 1 antibody
        • Activin receptor like kinase 1 antibody
        • Activin receptor-like kinase 1 antibody
        • ACVL1_HUMAN antibody
        • ACVRL1 antibody
        • ACVRLK1 antibody
        • ALK-1 antibody
        • ALK1 antibody
        • HHT antibody
        • HHT2 antibody
        • ORW2 antibody
        • Osler Rendu Weber syndrome 2 antibody
        • Serine/threonine protein kinase receptor R3 antibody
        • Serine/threonine-protein kinase receptor R3 antibody
        • SKR3 antibody
        • TGF B superfamily receptor type I antibody
        • TGF-B superfamily receptor type I antibody
        • TSR-I antibody
        • TSR1 antibody
        see all

      Images

      • Western blot - Anti-ALK-1 antibody (ab10179)
        Western blot - Anti-ALK-1 antibody (ab10179)
        Anti-ALK-1 antibody (ab10179) at 2 µg/ml + MCF7 lysate at 35 µg

        Developed using the ECL technique.

        Predicted band size: 56 kDa
        Observed band size: 60 kDa
        why is the actual band size different from the predicted?

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab10179? Please let us know so that we can cite the reference in this datasheet.

      ab10179 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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