Overview

  • Product name

    ALLM, calpain inhibitor
  • Description

    Potent, cell-permeable calpain inhibitor. Highly potent cathepsin inhibitor.
  • Biological description

    Potent, cell-permeable calpain inhibitor (Ki values and 120 and 230 nM at calpain I and II respectively). Highly potent cathepsin inhibitor (Ki values are 0.6 and 100 nM at cathepsin L and B respectively). Promotes caspase-dependent apoptosis in cancer cells. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 95%
  • CAS Number

    136632-32-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Arataki S  et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma 22:398-406 (2005). Read more (PubMed: 15785234) »
  • Yu R  et al. Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells. J Endocrinol 174:379-86 (2002). Read more (PubMed: 12208657) »
  • Sasaki T  et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J Enzyme Inhib 3:195-201 (1990). Read more (PubMed: 2079636) »

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