Overview

  • Product name

    ALLN, cysteine proteinase inhibitor
  • Description

    Potent, cell-permeable cysteine proteinase inhibitor
  • Biological description

    Potent, cell-permeable cysteine proteinase inhibitor (Ki values are 190 (calpain I), 220 (calpain II), 150 (cathepsin B) nM and 500 pM (cathepsin L). Promotes Bax-dependent apoptosis in cancer cells. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 95%
  • CAS Number

    110044-82-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Li SZ  et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun 437:325-30 (2013). Read more (PubMed: 23831472) »
  • Yamada M  et al. Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nat Med 15:1202-7 (2009). Read more (PubMed: 19734909) »
  • Donkor IO & Korukonda R Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position. Bioorg Med Chem Lett 18:4806-8 (2008). Read more (PubMed: 18694642) »

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