Overview

  • Product name

    Alloswitch-1, mGlu5 modulator
  • Description

    Photoswitchable allosteric mGlu5 modulator
  • Alternative names

    • Trans-alloswitch-1
  • Biological description

    Photoswitchable allosteric modulator selective for the metabotropic glutamate receptor mGlu5. Acts as a potent NAM (negative allosteric modulator) in dark or under green light but loses its NAM potency under violet light when photoisomerized.

  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-chloro-N-[2-methoxy-4-(pyridin-2-yldiazenyl)phenyl]benzamide
  • Molecular weight

    366.80
  • Molecular formula

    C19H15ClN4O2
  • PubChem identifier

    76853680
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • SMILES

    Clc1ccccc1C(=O)Nc3ccc(/N=N/c2ccccn2)cc3OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Dalton JA  et al. Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective. Curr Neuropharmacol 14:441-54 (2016). Read more (PubMed: 26391742) »
  • Pittolo S  et al. An allosteric modulator to control endogenous G protein-coupled receptors with light. Nat Chem Biol 10:813-5 (2014). Read more (PubMed: 25173999) »

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