Overview

  • Product name

    Aloe-emodin, Apoptotic and anticancer agent
  • Description

    Apoptotic and anticancer agent
  • Biological description

    Apoptotic and anticancer agent. AChE inhibitor (IC50 = 68 μM). Modulates oxidative stress. Shows antiproliferative effects via ERα inhibition. Shows neuroprotective and antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    481-72-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,8-Dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione

  • Molecular weight

    270.24
  • Molecular formula

    C15H10O5
  • PubChem identifier

    10207
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol (with heating)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3C2=O)CO)O
  • Source

    Aloe vera

  • Research areas

References

This product has been referenced in:

  • Tao L  et al. Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells. Bioorg Med Chem Lett 24:5385-5389 (2014). Read more (PubMed: 25453793) »
  • Huang PH  et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER a Inhibition. Evid Based Complement Alternat Med 2013:376123 (2013). Read more (PubMed: 23864887) »
  • Pecere T  et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res 60:2800-4 (2000). Read more (PubMed: 10850417) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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