Product nameAloisine, CDK and GSK-3 inhibitor
DescriptionCell-permeable, selective, potent, ATP-competitive inhibitor of CDKs and GSK-3.
- Aloisine RP106
Cell-permeable, selective, potent, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3 (IC50 values are 700nM, 1.5 µM, and 920 nM, respectively).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Mettey Y et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem 46:222-36 (2003). Read more (PubMed: 12519061) »