Aloisine, CDK and GSK-3 inhibitor (ab143751)

Overview

  • Product name

    Aloisine, CDK and GSK-3 inhibitor
  • Description

    Cell-permeable, selective, potent, ATP-competitive inhibitor of CDKs and GSK-3.
  • Alternative names

    • 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
    • Aloisine RP106
    • RP-106
  • Biological description

    Cell-permeable, selective, potent, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3 (IC50 values are 700nM, 1.5 µM, and 920 nM, respectively).

  • CAS Number

    496864-15-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
  • Molecular weight

    281.35
  • Molecular formula

    C17H19N3O
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Mettey Y  et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem 46:222-36 (2003). Read more (PubMed: 12519061) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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