Anti-alpha 1 Glycine Receptor antibody (ab166935)

Overview

  • Product name
    Anti-alpha 1 Glycine Receptor antibody
    See all alpha 1 Glycine Receptor primary antibodies
  • Description
    Goat polyclonal to alpha 1 Glycine Receptor
  • Host species
    Goat
  • Specificity
    The immunizing peptide represents part of the cytoplasmic domain. ab166935 is not expected to cross-react with other glycine receptor alpha proteins.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Dog, Human, Pig
  • Immunogen

    Synthetic peptide, corresponding to internal sequence amino acids 373-386 of Rat alpha 1 Glycine Receptor, isoform 2 (NP_037265.1).

  • Positive control
    • Mouse and Rat testis lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab166935 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 52 kDa.

Target

  • Function
    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • Involvement in disease
    Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLRA1 antibody
    • GLRA1_HUMAN antibody
    • Glycine receptor 48 kDa subunit antibody
    • Glycine receptor alpha 1 antibody
    • Glycine receptor strychnine-binding subunit antibody
    • Glycine receptor subunit alpha-1 antibody
    • Glycine receptor, alpha 1 subunit antibody
    • HKPX1 antibody
    • STHE antibody
    see all

Images

  • Anti-alpha 1 Glycine Receptor antibody (ab166935) at 0.3 µg/ml + Mouse testis lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 52 kDa

References

ab166935 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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