Overview

  • Product name

    Anti-alpha 1 Glycine Receptor/GLRA1 antibody
    See all alpha 1 Glycine Receptor/GLRA1 primary antibodies
  • Description

    Rabbit polyclonal to alpha 1 Glycine Receptor/GLRA1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human alpha 1 Glycine Receptor/GLRA1.
    Database link: P23415

  • General notes

     This product was previously labelled as alpha 1 Glycine Receptor

     

Properties

Applications

Our Abpromise guarantee covers the use of ab192508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.

Target

  • Function

    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • Involvement in disease

    Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GLRA1 antibody
    • GLRA1_HUMAN antibody
    • Glycine receptor 48 kDa subunit antibody
    • Glycine receptor alpha 1 antibody
    • Glycine receptor strychnine-binding subunit antibody
    • Glycine receptor subunit alpha-1 antibody
    • Glycine receptor, alpha 1 subunit antibody
    • HKPX1 antibody
    • STHE antibody
    see all

References

ab192508 has not yet been referenced specifically in any publications.

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