Overview

  • Product name

    Anti-alpha 2 Macroglobulin antibody
    See all alpha 2 Macroglobulin primary antibodies
  • Description

    Sheep polyclonal to alpha 2 Macroglobulin
  • Host species

    Sheep
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human alpha 2 Macroglobulin.
    Database link: P01023

  • Positive control

    • IHC-P: Human prostate and placenta tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml.

Target

  • Function

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
  • Tissue specificity

    Secreted in plasma.
  • Sequence similarities

    Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Developmental stage

    Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • A2m antibody
    • A2MG_HUMAN antibody
    • Alpha 2 M antibody
    • Alpha 2M antibody
    • Alpha-2-M antibody
    • Alpha-2-macroglobulin antibody
    • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody
    • CPAMD5 antibody
    • DKFZp779B086 antibody
    • FWP007 antibody
    • S863 7 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human prostate tissue stained for alpha 2 Macroglobulin using ab230780 at 10 µg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human placenta tissue stained for alpha 2 Macroglobulin using ab230780 at 10 µg/ml in immunohistochemical analysis.

References

ab230780 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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