Anti-Alpha B Crystallin antibody (ab166839)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Alpha B Crystallin antibody
See all Alpha B Crystallin primary antibodies -
Description
Rabbit polyclonal to Alpha B Crystallin -
Host species
Rabbit -
Specificity
ab166839 does not cross-react with Alpha A crystallin. -
Tested applications
Suitable for: ICC/IF, WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Chicken, Cow, Human -
Immunogen
Synthetic peptide conjugated to KLH corresponding to a region within Human Alpha B Crystallin.
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Positive control
- Human prostate nerve and brain cortex tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Storage buffer
Constituent: 100% Whole serum -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab166839 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF | Use at an assay dependent concentration. | |
| WB | 1/5000 - 1/10000. Detects a band of approximately 22 kDa. | |
| IHC-P | 1/200. |
Target
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Function
May contribute to the transparency and refractive index of the lens. -
Tissue specificity
Lens as well as other tissues. -
Involvement in disease
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
Sequence similarities
Belongs to the small heat shock protein (HSP20) family. -
Cellular localization
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
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Database links
- Entrez Gene: 396089 Chicken
- Entrez Gene: 281719 Cow
- Entrez Gene: 1410 Human
- Entrez Gene: 12955 Mouse
- Entrez Gene: 25420 Rat
- Omim: 123590 Human
- SwissProt: Q05713 Chicken
- SwissProt: P02510 Cow
see all -
Alternative names
- AACRYA antibody
- Alpha B crystallin antibody
- Alpha crystallin B chain antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody (ab166839)Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human prostate nerve tissue labeling Alpha B crystallin with ab166839 at 1/200 dilution. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody (ab166839)Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human brain cortex tissue labeling Alpha B crystallin with ab166839 at 1/200 dilution.
Protocols
Datasheets and documents
References
ab166839 has not yet been referenced specifically in any publications.
