Overview

  • Product name

    Anti-Alpha B Crystallin antibody [SP288]
    See all Alpha B Crystallin primary antibodies
  • Description

    Rabbit monoclonal [SP288] to Alpha B Crystallin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Synthetic peptide within Human Alpha B Crystallin aa 1-100 (N terminal). The exact sequence is proprietary.
    Database link: P02511

  • Positive control

    • IHC-P: Human renal cell carcinoma, melanoma, kidney, cerebellum, spinal cord and heart tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab226839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Primary incubation for 10 minutes at room temperature.

Target

  • Function

    May contribute to the transparency and refractive index of the lens.
  • Tissue specificity

    Lens as well as other tissues.
  • Involvement in disease

    Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
  • Sequence similarities

    Belongs to the small heat shock protein (HSP20) family.
  • Cellular localization

    Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • Information by UniProt
  • Database links

  • Alternative names

    • AACRYA antibody
    • Alpha B crystallin antibody
    • Alpha crystallin B chain antibody
    • Alpha(B)-crystallin antibody
    • Alpha-crystallin B chain antibody
    • CRYA2 antibody
    • Cryab antibody
    • CRYAB_HUMAN antibody
    • Crystallin alpha B antibody
    • Crystallin alpha polypeptide 2 antibody
    • CTPP2 antibody
    • Heat shock 20 kD like protein antibody
    • Heat shock protein beta 5 antibody
    • Heat shock protein beta-5 antibody
    • HspB5 antibody
    • Renal carcinoma antigen NY REN 27 antibody
    • Renal carcinoma antigen NY-REN-27 antibody
    • Rosenthal fiber component antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human renal cell carcinoma tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human melanoma tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human cerebellum tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human spinal cord tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human heart tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.

References

ab226839 has not yet been referenced specifically in any publications.

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