Product nameAnti-alpha + beta Synuclein antibody
See all alpha + beta Synuclein primary antibodies
DescriptionSheep polyclonal to alpha + beta Synuclein
SpecificityImmunogen sequence is 100% identical to alpha and beta and is similar to a lesser extent to gamma synuclein. This antibody cross reacts with beta and alpha synuclein but not to gamma synculein.
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Chicken
This antibody achieves excellent staining of Lewy bodies in Parkinson’s disease and Dementia with Lewy bodies disease tissue and gives excellent staining of glial inclusions in Multi System Atrophy tissue.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferConstituent: Whole serum
Purification notesFiltered serum.
Primary antibody notesThis antibody achieves excellent staining of Lewy bodies in Parkinson’s disease and Dementia with Lewy bodies disease tissue and gives excellent staining of glial inclusions in Multi System Atrophy tissue.
- Recombinant Human Alpha-synuclein protein (ab123758)
- Recombinant Human Alpha-synuclein protein (ab125808)
- Recombinant Human Alpha-synuclein protein (ab48842)
- Recombinant Human beta Synuclein protein (ab48853)
- Recombinant Human Alpha-synuclein (deleted ) protein (ab51173)
- Recombinant Human Alpha-synuclein (deleted ) protein (ab51176)
- Recombinant Human Alpha-synuclein (deleted ) protein (ab51186)
Our Abpromise guarantee covers the use of ab21975 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/1000 - 1/4000.|
|WB||1/2000 - 1/8000. Predicted molecular weight: 14 kDa.|
RelevanceSynucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson’s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson’s disease, Alzheimer’s disease and several other neurodegenerative illnesses.
Cellular localizationCytoplasmic. Membrane bound in dopaminergic neurons. Also found in the nucleus.
- Alpha synuclein antibody
- Beta synuclein antibody
- NACP antibody
ab21975 has not yet been referenced specifically in any publications.