α-Methyl-γ-hydroxy-1,N2-propano-2’-deoxyguanosine (Mixture of Diastereomers) (ab144781)

Overview

  • Product name

    α-Methyl-γ-hydroxy-1,N2-propano-2’-deoxyguanosine (Mixture of Diastereomers)
  • Description

    Genotoxic cyclic adduct of 2'-deoxyguanosine with crotonaldehyde
  • Alternative names

    • Cr-PdG
  • Biological description

    Genotoxic cyclic adduct of 2'-deoxyguanosine with crotonaldehyde. Histones accelerate cyclic 1,N2-propanoguanine adduct-formation of DNA.
  • CAS Number

    132014-87-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Hydroxy-3-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10-one
  • Molecular weight

    337.33
  • Molecular formula

    C14H19N5O5
  • PubChem identifier

    71750391
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in water and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC(N2C(=O)C3=C(NC2=N1)N(C=N3)[C@H]4CC([C@H](O4)CO)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yang IY  et al. Genotoxic mechanism for the major acrolein-derived deoxyguanosine adduct in human cells. Chem Res Toxicol 15:160-4 (2002). Read more (PubMed: 11849041) »
  • Gölzer P  et al. (E)-2-hexenal-induced DNA damage and formation of cyclic 1,N2-(1,3-propano)-2'-deoxyguanosine adducts in mammalian cells. Chem Res Toxicol 9:1207-13 (0). Read more (PubMed: 8902278) »

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