Overview

  • Product name
    Anti-alpha Sarcoglycan antibody
    See all alpha Sarcoglycan primary antibodies
  • Description
    Rabbit polyclonal to alpha Sarcoglycan
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 238-266 of Human alpha Sarcoglycan (NP_001129169.1, NP_000014.1).

  • Positive control
    • 293 cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab130657 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab130657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

Target

  • Function
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • Tissue specificity
    Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain.
  • Involvement in disease
    Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D) [MIM:608099]; also known as Duchenne-like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C.
  • Sequence similarities
    Belongs to the sarcoglycan alpha/epsilon family.
  • Cellular localization
    Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • 50 DAG antibody
    • 50 kDa dystrophin associated glycoprotein antibody
    • 50 kDa dystrophin-associated glycoprotein antibody
    • 50DAG antibody
    • 50kD DAG antibody
    • 59kDa antibody
    • A2 antibody
    • adhalin antibody
    • ADL antibody
    • Alpha SG antibody
    • Alpha-sarcoglycan antibody
    • Alpha-SG antibody
    • Asg antibody
    • DAG2 antibody
    • DMDA2 antibody
    • Dystroglycan 2 antibody
    • Dystroglycan-2 antibody
    • LGMD2D antibody
    • sarcoglycan, alpha (dystrophin-associated glycoprotein) antibody
    • SCARMD1 antibody
    • Sgca antibody
    • SGCA_HUMAN antibody
    see all

Images

  • Anti-alpha Sarcoglycan antibody (ab130657) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size: 43 kDa

References

ab130657 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab130657.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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