Overview

  • Product name

    Anti-alpha smooth muscle Actin antibody [ACTA2/791]
    See all alpha smooth muscle Actin primary antibodies
  • Description

    Mouse monoclonal [ACTA2/791] to alpha smooth muscle Actin
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
    Predicted to work with: Mouse, Rabbit, Chicken, Cow
  • Immunogen

    Recombinant full length protein corresponding to Human alpha smooth muscle Actin.
    Database link: P62736

  • Positive control

    • Human angiosarcoma, leiomyosarcoma, colon carcinoma and rat lung tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab220179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.25 - 0.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • Involvement in disease

    Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
  • Sequence similarities

    Belongs to the actin family.
  • Cellular localization

    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links

  • Alternative names

    • a actin antibody
    • AAT6 antibody
    • ACTA_HUMAN antibody
    • ACTA2 antibody
    • Actin alpha 2 smooth muscle aorta antibody
    • Actin aortic smooth muscle antibody
    • Actin, aortic smooth muscle antibody
    • ACTSA antibody
    • ACTVS antibody
    • Alpha 2 actin antibody
    • Alpha actin 2 antibody
    • Alpha cardiac actin antibody
    • alpha sma antibody
    • Alpha-actin-2 antibody
    • Cell growth inhibiting gene 46 protein antibody
    • Cell growth-inhibiting gene 46 protein antibody
    • GIG46 antibody
    • Growth inhibiting gene 46 antibody
    • MYMY5 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human angiosarcoma tissue labeling alpha smooth muscle Actin with ab220179 at 0.5 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human leiomyosarcoma tissue labeling alpha smooth muscle Actin with ab220179 at 0.5 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human colon carcinoma tissue labeling alpha smooth muscle Actin with ab220179 at 0.5 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Rat lung tissue labeling alpha smooth muscle Actin with ab220179 at 0.5 µg/ml.

References

ab220179 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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