Overview

  • Product name

    alpha-Tocotrienol, Form of vitamin E
  • Description

    Form of vitamin E. Lipophilic antioxidant agent.
  • Biological description

    Form of vitamin E. Lipophilic antioxidant agent. Tocotrienol β (ab145176), δ (ab144449) and γ (ab144448) analog. Induces apoptosis in cancer cells. Shows antitumor, neuroprotective and antioxidant effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    58864-81-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-2,5,7,8-Tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
  • Molecular weight

    424.68
  • Molecular formula

    C29H44O2
  • PubChem identifier

    5282347
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(=C2CC[C@@](OC2=C1C)(C)CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sato A  et al. A redox-silent analogue of tocotrienol inhibits cobalt(II) chloride-induced VEGF expression via Yes signaling in mesothelioma cells. Biol Pharm Bull 37:865-70 (2014). Read more (PubMed: 24790010) »
  • Nakamura T  et al. Location of a-tocopherol and a-tocotrienol to heterogeneous cell membranes and inhibition of production of peroxidized cholesterol in mouse fibroblasts. Springerplus 3:550 (2014). Read more (PubMed: 25279334) »
  • Sen CK  et al. Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease. J Am Coll Nutr 29:314S-323S (2010). Read more (PubMed: 20823491) »

Customer reviews and Q&As

Question
Answer

Unfortunately, this is not something that we determine as we do not test our products in vivo.

I would suggest performing a literature search to determine the half life of α-Tocotrienol.

From my research, I have found a paper which describes that the mean apparent elimination half-life of α-, γ- and δ-tocotrienols was estimated to be 4.4, 4.3 and 2.3 h, respectively, being between 4.5- to 8.7-fold shorter than that reported for α-tocopherol.

For more information, please read the following paper:

Tocotrienols in health and disease: the other half of the natural vitamin E family
Chandan K. Sen, Savita Khanna, and Sashwati Roy
Mol Aspects Med. 2007; 28(5-6): 692–728.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435257/

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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