Anti-alpha Tubulin (acetyl K40) antibody [6-11B-1] (ab24610)

Mouse monoclonal alpha Tubulin (acetyl K40) antibody [6-11B-1]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Sheep, Human, Monkey, Sea urchin. Cited in 106 publication(s).

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ab24610 has been referenced in 108 publications.

  • Choi YJ  et al. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet 104:45-54 (2019). PubMed: 30609407
  • Wormser O  et al. SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome. Eur J Hum Genet N/A:N/A (2019). PubMed: 30723319
  • Jaykumar AB  et al. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. JCI Insight 3:N/A (2018). PubMed: 30385718
  • Keremu A  et al. Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines. Cancer Chemother Pharmacol N/A:N/A (2018). PubMed: 30430228
  • Peng Y  et al. Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps. Allergy Asthma Clin Immunol 14:71 (2018). PubMed: 30459817
  • Yurchenko OV  et al. Nervous system development in the Pacific oyster, Crassostrea gigas (Mollusca: Bivalvia). Front Zool 15:10 (2018). PubMed: 29681988
  • Bamodu OA  et al. HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of hsa-miR-196a targeting BCR/ABL1. Exp Cell Res 370:519-530 (2018). PubMed: 30017934
  • Corrigan MA  et al. TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium. Sci Rep 8:3824 (2018). PubMed: 29491434
  • Shi W  et al. Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. Sci Rep 7:1866 (2017). ICC/IF . PubMed: 28500304
  • Ma Y  et al. Siva 1 inhibits proliferation, migration and invasion by phosphorylating Stathmin in ovarian cancer cells. Oncol Lett 14:1512-1518 (2017). PubMed: 28789373
  • Zheng C  et al. Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Mol Biol Cell 28:2786-2801 (2017). PubMed: 28835377
  • Cano-Rodriguez D  et al. TCTN2: a novel tumor marker with oncogenic properties. Oncotarget 8:95256-95269 (2017). PubMed: 29221125
  • Ishikawa S  et al. A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-ß1 treatment. Respir Res 18:195 (2017). PubMed: 29166920
  • Wang J  et al. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest 127:3075-3089 (2017). PubMed: 28737508
  • Schober T  et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun 8:14209 (2017). WB ; Human . PubMed: 28112205
  • Cha Y  et al. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Nat Cell Biol 19:445-456 (2017). WB ; Human . PubMed: 28436968
  • Kawasaki M  et al. Bardet-Biedl syndrome 3 regulates the development of cranial base midline structures. Bone 101:179-190 (2017). PubMed: 27170093
  • Jansens RJJ  et al. Pseudorabies virus US3-induced tunneling nanotubes contain stabilized microtubules, interact with neighbouring cells via cadherins and allow intercellular molecular communication. J Virol N/A:N/A (2017). PubMed: 28747498
  • O'Hare Doig RL  et al. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neurosci 18:62 (2017). PubMed: 28806920
  • Zhan D  et al. Basic fibroblast growth factor increases IFT88 expression in chondrocytes. Mol Med Rep 16:6590-6599 (2017). PubMed: 28901443
  • Farrugia AJ & Calvo F Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts. Small GTPases 8:49-57 (2017). ICC/IF . PubMed: 27248291
  • Patschan D  et al. Endothelial Colony Forming Cells (ECFCs) in murine AKI - implications for future cell-based therapies. BMC Nephrol 18:53 (2017). IHC-P ; Mouse . PubMed: 28166726
  • Zaidman NA  et al. Large-conductance Ca(2+) -activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium. J Physiol 595:4631-4645 (2017). Human . PubMed: 28481415
  • Jiang S  et al. Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway. Mol Med Rep 14:1891-900 (2016). WB ; Human . PubMed: 27432616
  • Barbutti I  et al. CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells. Oncotarget 7:68385-68396 (2016). WB . PubMed: 27588395
  • Merigo F  et al. Molecules implicated in glucose homeostasis are differentially expressed in the trachea of lean and obese Zucker rats. Eur J Histochem 60:2557 (2016). PubMed: 26972710
  • Sánchez A  et al. Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium. EMBO Rep 17:708-23 (2016). PubMed: 27113750
  • Pfaltzgraff ER  et al. Loss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities. Mol Biol Cell 27:1990-9 (2016). PubMed: 27146114
  • Courtheoux T  et al. Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase. Nat Commun 7:12810 (2016). ICC/IF ; Human . PubMed: 27641145
  • Stoetzel C  et al. A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. Nat Commun 7:13586 (2016). ICC/IF ; Human . PubMed: 27882921
  • Kenyon EJ  et al. Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Dev Biol 16:23 (2016). ICC/IF . PubMed: 27391801
  • Shi X  et al. Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes. Int J Mol Med 38:123-30 (2016). ICC/IF ; Rat . PubMed: 27220726
  • Ide T  et al. Identification of the agg1 mutation responsible for negative phototaxis in a "wild-type" strain of Chlamydomonas reinhardtii. Biochem Biophys Rep 7:379-385 (2016). PubMed: 28955929
  • Gilpin SE  et al. Regenerative potential of human airway stem cells in lung epithelial engineering. Biomaterials 108:111-9 (2016). PubMed: 27622532
  • Wali G  et al. Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia. Sci Rep 6:27004 (2016). PubMed: 27229699
  • Tosoni K  et al. Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance. PLoS One 11:e0149550 (2016). PubMed: 26926476
  • Li L  et al. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol 18:418-30 (2016). PubMed: 26999738
  • Warner JF  et al. Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. Dev Biol 411:314-324 (2016). PubMed: 26872875
  • Machado-Neto JA  et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta 1853:583-93 (2015). PubMed: 25523139
  • Lee KL  et al. The primary cilium functions as a mechanical and calcium signaling nexus. Cilia 4:7 (2015). PubMed: 26029358
  • Vladar EK  et al. Observing planar cell polarity in multiciliated mouse airway epithelial cells. Methods Cell Biol 127:37-54 (2015). PubMed: 25837385
  • Herms A  et al. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun 6:7176 (2015). WB . PubMed: 26013497
  • Jeanson L  et al. RSPH3 Mutations Cause Primary Ciliary Dyskinesia with Central-Complex Defects and a Near Absence of Radial Spokes. Am J Hum Genet 97:153-62 (2015). PubMed: 26073779
  • Zheng J  et al. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). Eur J Immunol 45:2834-46 (2015). PubMed: 26255980
  • Yuan Y  et al. Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1?. PLoS One 10:e0135017 (2015). ICC/IF ; Human . PubMed: 26263164
  • Mills EA  et al. Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis. Proc Natl Acad Sci U S A 112:10509-14 (2015). PubMed: 26240339
  • Song BW  et al. 1H-pyrrole-2,5-dione-based small molecule-induced generation of mesenchymal stem cell-derived functional endothelial cells that facilitate rapid endothelialization after vascular injury. Stem Cell Res Ther 6:174 (2015). ICC/IF ; Rat . PubMed: 26373837
  • Matsumoto SE  et al. The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties. Hum Mol Genet 24:6403-16 (2015). PubMed: 26374846
  • Wright CE  et al. LGN Directs Interphase Endothelial Cell Behavior via the Microtubule Network. PLoS One 10:e0138763 (2015). PubMed: 26398908
  • Liu N  et al. New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry. Sci Rep 5:16869 (2015). Mouse . PubMed: 26581825
  • Chen CT  et al. Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation. Mol Biol Cell 26:4562-76 (2015). ICC/IF . PubMed: 26466679
  • Nguyen AM  et al. The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling. Biol Open 4:1733-8 (2015). WB, ICC/IF ; Mouse . PubMed: 26603473
  • Cao J  et al. Circovirus transport proceeds via direct interaction of the cytoplasmic dynein IC1 subunit with the viral capsid protein. J Virol 89:2777-91 (2015). PubMed: 25540360
  • Bizet AA  et al. Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun 6:8666 (2015). PubMed: 26487268
  • Siriwardana NS  et al. The novel function of JADE1S in cytokinesis of epithelial cells. Cell Cycle 14:2821-34 (2015). PubMed: 26151225
  • Yang TT  et al. Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone. Sci Rep 5:14096 (2015). PubMed: 26365165
  • Machado-Neto JA  et al. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells. Oncotarget 6:29573-84 (2015). PubMed: 26356819
  • Guedes-Dias P  et al. HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. Biochim Biophys Acta 1852:2484-93 (2015). PubMed: 26300485
  • Oyama K  et al. Triggering of high-speed neurite outgrowth using an optical microheater. Sci Rep 5:16611 (2015). PubMed: 26568288
  • Coughlin TR  et al. Primary cilia exist in a small fraction of cells in trabecular bone and marrow. Calcif Tissue Int 96:65-72 (2015). PubMed: 25398598
  • Graffe M  et al. A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals. J Gen Physiol 146:109-17 (2015). ICC/IF ; Goldfish . PubMed: 26123197
  • Brockman-Schneider RA  et al. Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication. PLoS One 9:e86755 (2014). IHC-P ; Human . PubMed: 24475177
  • Saraga M  et al. Mechanism of cystogenesis in nephrotic kidneys: a histopathological study. BMC Nephrol 15:3 (2014). IHC-P ; Human . PubMed: 24397250
  • Kubo T  et al. A conserved flagella-associated protein in Chlamydomonas, FAP234, is essential for axonemal localization of tubulin polyglutamylase TTLL9. Mol Biol Cell 25:107-17 (2014). IF . PubMed: 24196831
  • Gray JE  et al. A phase I, pharmacokinetic, and pharmacodynamic study of panobinostat, an HDAC inhibitor, combined with erlotinib in patients with advanced aerodigestive tract tumors. Clin Cancer Res 20:1644-55 (2014). IHC ; Human . PubMed: 24429877
  • Zhu Y  et al. Role of tumor necrosis factor alpha-induced protein 1 in paclitaxel resistance. Oncogene 33:3246-55 (2014). PubMed: 23912453
  • Kuhlmann K  et al. The membrane proteome of sensory cilia to the depth of olfactory receptors. Mol Cell Proteomics 13:1828-43 (2014). PubMed: 24748648
  • Kero D  et al. Expression of Ki-67, Oct-4, ?-tubulin and a-tubulin in human tooth development. Arch Oral Biol 59:1119-29 (2014). Human . PubMed: 25062118
  • Lee YL  et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell 25:2919-33 (2014). PubMed: 25103236
  • Del Nagro C  et al. Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem 289:35182-92 (2014). WB . PubMed: 25355314
  • Castellano JF  et al. Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging. Hippocampus 24:1006-16 (2014). PubMed: 24753063
  • Fan Y  et al. Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia. Biol Open 3:494-502 (2014). ICC/IF ; Human . PubMed: 24857849
  • Firth AL  et al. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 111:E1723-30 (2014). PubMed: 24706852
  • Fu X  et al. Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons. J Neurosci 33:709-21 (2013). PubMed: 23303949
  • Bartholomeeusen K  et al. Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J Biol Chem 288:14400-7 (2013). PubMed: 23539624
  • Villumsen BH  et al. A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J 32:3029-40 (2013). Human . PubMed: 24121310
  • Schaub JR & Stearns T The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content. Mol Biol Cell 24:453-64 (2013). ICC/IF ; Mouse . PubMed: 23264467
  • Parker JC  et al. Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell model. PLoS One 8:e61023 (2013). ICC/IF ; Human . PubMed: 23671562
  • Luijten MN  et al. Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet 22:4383-4397 (2013). PubMed: 23784378
  • Blaydon DC  et al. Mutations in AQP5, Encoding a Water-Channel Protein, Cause Autosomal-Dominant Diffuse Nonepidermolytic Palmoplantar Keratoderma. Am J Hum Genet N/A:N/A (2013). PubMed: 23830519
  • Huang YA  et al. Microtubule-associated type II protein kinase A is important for neurite elongation. PLoS One 8:e73890 (2013). ICC/IF ; Mouse . PubMed: 23967353
  • Shaw JL & Chang KT Nebula/DSCR1 Upregulation Delays Neurodegeneration and Protects against APP-Induced Axonal Transport Defects by Restoring Calcineurin and GSK-3ß Signaling. PLoS Genet 9:e1003792 (2013). PubMed: 24086147
  • Liesz A  et al. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J Neurosci 33:17350-62 (2013). WB . PubMed: 24174668
  • Liu X  et al. The p38-interacting protein (p38IP) regulates G2/M progression by promoting a-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem 288:36648-61 (2013). Human . PubMed: 24220028
  • Vukojevic K  et al. Developmental patterns of Ki-67, Oct-4 and a-tubulin proteins expression in the human spinal cord. Acta Histochem N/A:N/A (2013). Human . PubMed: 24373696
  • Kott E  et al. Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects. Am J Hum Genet 93:561-70 (2013). PubMed: 23993197
  • Abrahamsen G  et al. A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. Dis Model Mech 6:489-502 (2013). WB . PubMed: 23264559
  • Merigo F  et al. Glucose transporter/T1R3-expressing cells in rat tracheal epithelium. J Anat 221:138-50 (2012). PubMed: 22640462
  • Stowe TR  et al. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Mol Biol Cell 23:3322-35 (2012). ICC/IF . PubMed: 22767577
  • Grebenová D  et al. Proteins implicated in the increase of adhesivity induced by suberoylanilide hydroxamic acid in leukemic cells. J Proteomics : (2012). PubMed: 23022583
  • Perera S  et al. Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle. J Muscle Res Cell Motil 33:107-22 (2012). PubMed: 22426552
  • Dempsey GT  et al. Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nat Methods 8:1027-36 (2011). PubMed: 22056676
  • Liu YW  et al. Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic 12:1620-33 (2011). PubMed: 21762456
  • Perera S  et al. Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol 351:46-61 (2011). ICC/IF ; Mouse . PubMed: 21185285
  • Sanchez CG  et al. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 32:964-72 (2011). ICC/IF ; Human . PubMed: 21317300
  • Juuti-Uusitalo K  et al. Differential effects of TNF (TNFSF2) and IFN-? on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. PLoS One 6:e22967 (2011). ICC/IF ; Human . PubMed: 21853060
  • Byfield FJ  et al. Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa. J Immunol 187:6402-9 (2011). PubMed: 22095714
  • Loebel DA  et al. Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development 138:4511-22 (2011). PubMed: 21903671
  • Parker J  et al. A 3-D well-differentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic cells. Pediatr Res 67:17-22 (2010). IHC-P ; Human . PubMed: 19755931
  • Yao X  et al. Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway. Am J Respir Crit Care Med 182:1228-38 (2010). IHC-Fr ; Mouse . PubMed: 20622028
  • Wong AP  et al. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Invest 119:336-48 (2009). ICC/IF ; Mouse . PubMed: 19164856
  • Sha Y  et al. A critical role for CHIP in the aggresome pathway. Mol Cell Biol 29:116-28 (2009). WB ; Human . PubMed: 18955503
  • Shim SY  et al. Ndel1 Controls the Dynein-mediated Transport of Vimentin during Neurite Outgrowth. J Biol Chem 283:12232-40 (2008). WB ; Human . PubMed: 18303022
  • Toth C  et al. Ndel1 promotes axon regeneration via intermediate filaments. PLoS ONE 3:e2014 (2008). WB ; Mouse . PubMed: 18431495
  • Shim SY  et al. Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons. J Neurosci 28:3604-14 (2008). PubMed: 18385319
  • Rohatgi R  et al. Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease cyst-lining renal epithelial cells. Am J Physiol Renal Physiol 294:F890-9 (2008). PubMed: 18256315
  • Donnelly E  et al. The primary cilium of connective tissue cells: imaging by multiphoton microscopy. Anat Rec (Hoboken) 291:1062-73 (2008). IHC-Fr ; Mouse . PubMed: 18727071
  • Rock JR  et al. The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol 321:141-9 (2008). IHC-P ; Mouse . PubMed: 18585372

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