Overview

  • Product name
    alpha Tubulin peptide

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab195584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes

    This is the blocking peptide for ab106375

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 99.88% PBS, 0.1% BSA

General Info

  • Alternative names
    • Alpha-tubulin 1
    • ALS22
    • B ALPHA 1
    • bA408E5.3
    • H2 ALPHA
    • Hum a tub1
    • Hum a tub2
    • LIS3
    • MGC171407
    • MGC55332
    • TBA4A_HUMAN
    • Testis-specific alpha-tubulin
    • TUBA1
    • TUBA1A
    • tuba1l
    • Tuba4a
    • Tubulin alpha
    • Tubulin alpha 1 chain
    • Tubulin alpha-1 chain
    • tubulin alpha-1B chain
    • Tubulin alpha-4A chain
    • Tubulin H2-alpha
    • Tubulin, alpha 1 (testis specific)
    • tubulin, alpha 1, like
    • Tubulin, alpha 4a
    • Tubulin, alpha, testis-specific
    • Tubulin, alpha-1
    see all
  • Function
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • Sequence similarities
    Belongs to the tubulin family.
  • Post-translational
    modifications
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
    Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
  • Cellular localization
    Cytoplasm > cytoskeleton.
  • Information by UniProt

References

ab195584 has not yet been referenced specifically in any publications.

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