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  1. Link

    alpha-tubulin-peptide-ab195584.pdf

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Tags & Cell Markers Subcellular Markers Cytoskeleton Microtubules
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alpha Tubulin peptide (ab195584)

  • Datasheet
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Key features and details

  • Suitable for: Blocking

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Description

  • Product name

    alpha Tubulin peptide
  • Animal free

    No
  • Nature

    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab195584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab106375

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 99.88% PBS, 0.1% BSA

General Info

  • Alternative names

    • Alpha-tubulin 1
    • ALS22
    • B ALPHA 1
    • bA408E5.3
    • H2 ALPHA
    • Hum a tub1
    • Hum a tub2
    • LIS3
    • MGC171407
    • MGC55332
    • TBA4A_HUMAN
    • Testis-specific alpha-tubulin
    • TUBA1
    • TUBA1A
    • tuba1l
    • Tuba4a
    • Tubulin alpha
    • Tubulin alpha 1 chain
    • Tubulin alpha-1 chain
    • tubulin alpha-1B chain
    • Tubulin alpha-4A chain
    • Tubulin H2-alpha
    • Tubulin, alpha 1 (testis specific)
    • tubulin, alpha 1, like
    • Tubulin, alpha 4a
    • Tubulin, alpha, testis-specific
    • Tubulin, alpha-1
    see all
  • Function

    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • Sequence similarities

    Belongs to the tubulin family.
  • Post-translational
    modifications

    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
    Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
  • Cellular localization

    Cytoplasm > cytoskeleton.
  • Target information above from: UniProt accession P68366 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab195584? Please let us know so that we can cite the reference in this datasheet.

ab195584 has not yet been referenced specifically in any publications.

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