Anti-ALR/HPO antibody (ab196498)
Key features and details
- Rabbit polyclonal to ALR/HPO
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-ALR/HPO antibody
See all ALR/HPO primary antibodies -
Description
Rabbit polyclonal to ALR/HPO -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment within Human ALR/HPO (C terminal). The exact sequence is proprietary.
Database link: P55789 -
Positive control
- MCF7, 293T and HepG2 cell lysates
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab196498 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/2000. Predicted molecular weight: 23 kDa.
|
Notes |
---|
WB
1/500 - 1/2000. Predicted molecular weight: 23 kDa. |
Target
-
Function
Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs.
Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. -
Tissue specificity
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. -
Involvement in disease
Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency. -
Sequence similarities
Contains 1 ERV/ALR sulfhydryl oxidase domain. -
Cellular localization
Mitochondrion intermembrane space and Cytoplasm. Secreted. - Information by UniProt
-
Database links
- Entrez Gene: 2671 Human
- Omim: 600924 Human
- SwissProt: P55789 Human
- Unigene: 726325 Human
-
Alternative names
- ALR_HUMAN antibody
- Augmenter of liver regeneration antibody
- ERV1 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab196498 has not yet been referenced specifically in any publications.