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    alsterpaullone-cyclin-dependent-kinase-cdk-and-gsk-3beta-inhibitor-ab141070.pdf

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Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)

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Chemical Structure - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)
  • Functional Studies - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)

Key features and details

  • Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor
  • CAS Number: 237430-03-4
  • Purity: > 96%
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor
  • Description

    Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor
  • Biological description

    Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.
  • Purity

    > 96%
  • CAS Number

    237430-03-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one
  • Molecular weight

    293.28
  • Molecular formula

    C16H11N3O3
  • PubChem identifier

    5005498
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [O-][N+](=O)c4cc3c(NC1C3CC(=O)Nc2ccccc12)cc4
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Cell Cycle
    • Cyclins
    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Cdks
    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Cdk Regulators
    • Neuroscience
    • Neurology process
    • Notch Pathway
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • SMADs
    • Cell Biology
    • Cell Cycle
    • Cyclins
    • Cyclin B Family
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Neuroscience
    • Neurotransmission
    • Intracellular Signaling
    • Regulation
    • Neuroscience
    • Neurology process
    • Neurogenesis
    • Stem Cells
    • Signaling Pathways
    • Wnt
    • Cytoplasmic
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Cyclins
    • Cyclin B Family
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Kinases/Phosphatases
    • Cdk Regulators
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Kinases/Phosphatases
    • Cdks
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • SMADs
    • Stem Cells
    • Signaling Pathways
    • Notch
    • Cytoplasmic
    • Stem Cells
    • Signaling Pathways
    • TGF beta
    • Cytoplasmic
    • Cancer
    • Cell cycle
    • Cell division
    • Cancer
    • Cell cycle
    • Cyclins
    • Cyclin B family
    • Cancer
    • Cell cycle
    • Kinases/phosphatases
    • Cdks
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • SMAD family
    • Cardiovascular
    • Atherosclerosis
    • Diabetes associated
    • Cardiovascular
    • Heart
    • Apoptosis
    • Cardiovascular
    • Heart
    • Hypertrophy
    • Other
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of carbohydrates
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    • Integration of energy metabolism
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    • Cancer Metabolism
    • Response to hypoxia
    • Biochemicals
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    • Biochemicals
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Carbohydrate metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Energy transfer pathways
    • Integration of energy
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Hypoxia
    • Metabolism
    • Types of disease
    • Diabetes
    • Metabolism
    • Types of disease
    • Obesity
    • Metabolism
    • Types of disease
    • Heart disease
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
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    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Heart disease
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Hypertension
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Obesity
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Stroke
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors

Images

  • Chemical Structure - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)
    Chemical Structure - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)
    2D chemical structure image of ab141070, Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor
  • Functional Studies - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)
    Functional Studies - Alsterpaullone, cyclin-dependent kinase (CDK) and GSK-3beta inhibitor (ab141070)
    ab32505 staining AKT1 in SK-N-SH cells treated with alsterpaullone (ab141070), by ICC/IF. Decrease of AKT1 expression correlates with increased concentration of alsterpaullone, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab141070 (alsterpaullone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32505 (1/200 dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab141070? Please let us know so that we can cite the reference in this datasheet.

ab141070 has not yet been referenced specifically in any publications.

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