Overview

  • Product name

    Alternariol-9-methyl ether, apoptotic agent
  • Description

    Mycotoxin. Apoptotic agent.
  • Alternative names

    • Alternariol monomethyl ether
  • Biological description

    Mycotoxin. Apoptotic agent. Various pharmacological effects. Enhances the proportion of the transcription factor Nrf2 in the nucleus. Shows similar effects as Alternariol (ab143355). Modulates cellular redox status. Induces AhR/ARNT. Inhibits cholinesterase.
  • Purity

    > 98%
  • CAS Number

    23452-05-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,7-Dihydroxy-9-methoxy-1-methylbenzo[c]chromen-6-one
  • Molecular weight

    272.25
  • Molecular formula

    C15H12O5
  • PubChem identifier

    5360741
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tiessen C  et al. Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether. Toxicol Lett 216:23-30 (2013). Read more (PubMed: 23154127) »
  • Schreck I  et al. The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor. Arch Toxicol 86:625-32 (2012). Read more (PubMed: 22120949) »
  • Burkhardt B  et al. Oxidative metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in precision-cut rat liver slices in vitro. Mol Nutr Food Res 55:1079-86 (2011). Read more (PubMed: 21351248) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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