Overview

  • Product name

    AM251, CB1 receptor antagonist / inverse agonist
  • Description

    CB1 receptor antagonist / inverse agonist
  • Biological description

    Cannabinoid CB1 receptor antagonist / inverse agonist (Ki = 7.5 nM). Displays 306-fold selectivity over CB2 receptors. Anorectic and antidepressant in vivo.
  • Purity

    > 99%
  • CAS Number

    183232-66-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Shearman LP  et al. Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice. Behav Pharmacol 14:573-82 (2003). Read more (PubMed: 14665974) »
  • Lan R  et al. Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 42:769-76 (1999). Read more (PubMed: 10052983) »
  • Gatley SJ  et al. Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci 61:PL 191-7 (1997). Read more (PubMed: 9335234) »
See all 17 Publications for this product

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