Overview

  • Product name

    AM580, RARalpha agonists
  • Description

    Selective RARα agonists
  • Biological description

    Selective RARα agonists (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    102121-60-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bosch A  et al. Reversal by RARa agonist Am580 of c-Myc-induced imbalance in RARa/RAR? expression during MMTV-Myc tumorigenesis. Breast Cancer Res 14:R121 (2012). Read more (PubMed: 22920668) »
  • Charton J  et al. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorg Med Chem Lett 19:489-92 (2009). Read more (PubMed: 19058965) »
  • Gianní M  et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood 87:1520-31 (1996). Read more (PubMed: 8608243) »
  • Tamura K  et al. Synthetic retinoids, retinobenzoic acids, Am80, Am580 and Ch55 regulate morphogenesis in chick limb bud. Cell Differ Dev 32:17-26 (1990). Read more (PubMed: 2090329) »

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